modeling
Liver, Gallbladder Cancer Pharmacogenomics Investigated with Organoid Multiomics
Researchers profiled multiomic features and drug sensitivity patterns in dozens of patient-derived tumor organoids established with samples from Chinese hepatobiliary cancer patients.
Congenital Heart Defect Features of Down Syndrome Spelled Out with Transcriptomics, Mouse Models
Increased DYRK1A gene dosage led to altered expression of mitochondrial and cell proliferation genes in developing cardiac muscle cells, while DYRK1A inhibitors restored activity.
Cervical Cancer Multiomic Study Uncovers Informative Intratumor Heterogeneity States
With single-cell, spatial, and experimental approaches, researchers defined eight "meta-programs" linked to the tumor immune microenvironment and clinical features.
Liquid Biopsy-Based Colorectal Cancer Screening Lacks Cost-Effectiveness, Economic Analysis Finds
A simulation study suggests colonoscopy remains the most cost-effective CRC screening method, as liquid biopsy carries a far higher price per life-year gained.
Preterm Birth Biology Unraveled With Multiomics, Machine Learning
A multiomic analysis in low- and middle-income countries pointed to some of the genes and processes contributing to known epidemiological risk factors for preterm birth.