The International Mouse Phenotyping Consortium has systematically studied knockout mice to find new disease models and candidate disease genes.
In PLOS this week: loci linked to body mass index measurements, long non-coding RNA expression and urothelial carcinoma prognosis, and more.
VISION aims to provide validated regulatory modules, quantitative models for gene regulation, and guides for translating research from mouse models to human.
The researchers' findings could have wide-ranging implications for how the modeling tool should be used and how reliable the data from it is in biodiversity and evolution studies.
Analysis of a gene associated with basal progenitor cell expansions in the brain suggests a single splice site change led to human-specific forms of the gene transcript.
The model could shift which patients receive gene expression profiling assays but might not change the number of tests ordered.
Jax researchers will aim to study why some individuals are more likely to start using drugs, or to get addicted to them.
The study found that combining whole-genome expression or genome-wide methylation data with clinical data improves survival predictions in breast cancer cases.
Early results of a study suggest at least some recurrent gene mutations differ by breed for dogs affected by B-cell and/or T-cell lymphomas.
The African turquoise killifish, which lives only four to six months, has been transformed into a platform for genetic research with the help of CRISPR/Cas9 genome editing.
Using DNA to sketch crime victims might not be a great idea, the NYTimes says.
Science has its own problem with sexual harassment. What do we do with the research these abusers produce, Wired asks.
Senate Republicans led by Senator Rand Paul (R-KY) are trying to change how the government funds basic research, reports ScienceInsider.
In Science this week: combining genomics and ecology to better understand the effects of natural selection on evolution, and more.