modeling | GenomeWeb

modeling

Analysis of a gene associated with basal progenitor cell expansions in the brain suggests a single splice site change led to human-specific forms of the gene transcript.

The model could shift which patients receive gene expression profiling assays but might not change the number of tests ordered.

Jax researchers will aim to study why some individuals are more likely to start using drugs, or to get addicted to them.

The study found that combining whole-genome expression or genome-wide methylation data with clinical data improves survival predictions in breast cancer cases.

Early results of a study suggest at least some recurrent gene mutations differ by breed for dogs affected by B-cell and/or T-cell lymphomas.

african killifish

The African turquoise killifish, which lives only four to six months, has been transformed into a platform for genetic research with the help of CRISPR/Cas9 genome editing.

A computational model developed by researchers at Johns Hopkins and Harvard Universities has provided a possible explanation for why HIV treatment regimens that include protease inhibitors fail even though there are no observed resistance mutations in the viral genome.

The algorithm, which was developed by researchers at MIT and validated by a team at Novartis, lets users identify regions on antibodies that are prone to aggregation and then predict mutations to improve the stability of biotherapeutic formulations.

The collaboration is the third that Sage has announced with a major pharmaceutical firm, adding to existing agreements with Merck and Pfizer.

The two firms' combined modeling and analysis will integrate genomic, transcriptomic, in vitro, animal, and clinical data in a quantitative model.

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In Science this week: metagenomic-based technique for determining protein structure, and more.

An academic laments the rise of narcissism in the sciences, the Guardian reports.

Outgoing FDA commissioner Robert Califf writes in an editorial that the agency can help boost innovation.

The Trump transition team has asked NIH Director Francis Collins to remain at his post, though it's unclear for how long that will be.