modeling
New Grail Publication Explores Optimal Liquid Biopsy MCED Test Interval for Mortality Impact
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Company investigators calculated the expected reduction in late-stage cancer diagnoses and projected drops in mortality for different screening schedules in different models of cancer growth.
All children and adolescents with cancer in Ireland, including those who relapse following treatment, will be offered enrollment in the project.
Liver, Gallbladder Cancer Pharmacogenomics Investigated with Organoid Multiomics
Researchers profiled multiomic features and drug sensitivity patterns in dozens of patient-derived tumor organoids established with samples from Chinese hepatobiliary cancer patients.
Congenital Heart Defect Features of Down Syndrome Spelled Out with Transcriptomics, Mouse Models
Increased DYRK1A gene dosage led to altered expression of mitochondrial and cell proliferation genes in developing cardiac muscle cells, while DYRK1A inhibitors restored activity.
Cervical Cancer Multiomic Study Uncovers Informative Intratumor Heterogeneity States
With single-cell, spatial, and experimental approaches, researchers defined eight "meta-programs" linked to the tumor immune microenvironment and clinical features.