mitochondrial genomics

The US-based team that performed mitochondrial replacement therapy publishes its approach; editorial describes its weaknesses.

This Week in PLOS

In PLOS this week: chromosomal insertion mechanisms, phylogeographic analysis of the Crimean Congo hemorrhagic fever virus, and more.

The test is based on MDNA's Mitomic technology, which enables the isolation of mitochondrial DNA in circulation that may be used as biomarkers.

Using mitochondrial sequence data for hundreds of simplex families, investigators found predicted pathogenic heteroplasmic mutations were over-represented.

Researchers have filled in an important gap in the historical record for global malaria distribution with these missing European strain sequences.

Researchers have discovered that what was thought to be one far-roaming species is actually four separate and genetically distinct groups.

Researchers have conducted preclinical studies on pronuclear transplantation, showing some success.

This Week in Nature

In Nature this week: mitochondrial genome competition, and more.

Continuity in mitochondrial genomes present at an archeological site in Lima suggests cultural diffusion contributed to expansion of an imperialist Wari group.

The researchers found evidence of a single major dispersal event in non-African populations, and discovered an unknown European population turnover.

Pages

While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.