mitochondrial genomics

By sequencing a handful of individuals who lived in Morocco some 13,900 to 15,100 years ago, investigators found clues to past population mergers in North Africa.

A mitochondrial genome- and Y chromosome marker-based analysis suggests the Chachapoyas population was not completely replaced by Incas as previously believed.

University of Pennsylvania researchers sequenced single mitochondria, which they noted could be used to track the development of mitochondrial disease.

The US-based team that performed mitochondrial replacement therapy publishes its approach; editorial describes its weaknesses.

This Week in PLOS

In PLOS this week: chromosomal insertion mechanisms, phylogeographic analysis of the Crimean Congo hemorrhagic fever virus, and more.

The test is based on MDNA's Mitomic technology, which enables the isolation of mitochondrial DNA in circulation that may be used as biomarkers.

Using mitochondrial sequence data for hundreds of simplex families, investigators found predicted pathogenic heteroplasmic mutations were over-represented.

Researchers have filled in an important gap in the historical record for global malaria distribution with these missing European strain sequences.

Researchers have discovered that what was thought to be one far-roaming species is actually four separate and genetically distinct groups.

Researchers have conducted preclinical studies on pronuclear transplantation, showing some success.

Pages

The United Nations is to consider a ban on field testing gene drives at a meeting being held next week, Technology Review reports.

The Associated Press reports that gene-edited food may soon be for sale.

The US Department of Health and Human Services is beginning a series of meetings on human fetal tissue research, Stat News reports.

In Cell this week: epigenetic change linked to glioblastomas, rare and low-frequency variants contributing to multiple sclerosis risk, and more.