miRNA/RNAi

The deal gives Arrowhead access to technologies developed by Novartis, a license to Alnylam intellectual property, and a pipeline of three preclinical RNAi drug candidates.

The new company will be focused entirely on hepatitis B, although officials previously said that Tekmira's other non-HBV RNAi programs would continue to advance.

The company was founded in 1999 to provide high-throughput target discovery and validation services for academic and industry partners.

The approach is designed to overcomes many of the limitations of existing techniques such as the cost of developing and maintaining knockout mice.

The method involves expressing long dsRNA in plant chloroplasts to prevent them from being processed into less-effective siRNAs.

Identification of microRNAs (miRNAs) in fecal samples as biomarkers for gastroenterological cancers
Method for determining the origin of a sample
RNA interference-mediating small RNA molecules
Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules
Methods and compositions for the specific inhibition of androgen receptor by double-stranded RNA
Individualized cancer therapy

In Nature this week: omic analysis of permafrost microbes, hookworm genome, and more.

Biologists turn to environmental DNA sampling to determine whether elusive or invasive species are shedding DNA in a given area.

Rob Knight writes at Scientific American that microbiome studies are about to break out of the laboratory.

Harold Varmus, the director of the National Cancer Institute, has announced that he is stepping down after nearly five years.