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miRNA

Papers of Note: Aug 6, 2009

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RNAi-Related Papers Published July 2009

In the advance online version of Nucleic Acids Research, Santaris investigators reported data identifying miR-155, an miRNA involved in immune-system regulation, as a possible therapeutic target for chronic inflammatory diseases such as rheumatoid arthritis.

Papers of Note: Jul 9, 2009

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RNAi-Related Papers Published June 2009

Using a technique called HITS-CLIP, researchers from Rockefeller University have created a map of microRNA-messenger RNA interactions in the mouse brain.

The release of the data comes on the heels of a publication in Cell showing that therapeutic miRNA delivery could suppress tumorigenesis in a mouse model of liver cancer, which Mirna's CEO said bolsters the company's strategy.

The method, which is detailed in the current issue of Genome Biology, involves using the mean expression value of all expressed miRNAs in a given sample.

The company's lab is cleared in 48 states. The firm also said that it could earn $17 million through a license with Prometheus Laboratories.

The firm launched three microRNA-based tests during the fourth quarter, and posted a profit due to a capital gain on the sale of Auction Rate Securities to Credit Suisse. However, Rosetta only has enough cash to fund operations through mid-2010 and said that it may seek to raise additional funds.

An Affy spokesperson said the firm's interest in the market is an extension of its gene-expression profiling play, and said several "key advantages" over rival tools could enable it to profit in the market, which is poised to grow 25 percent through 2015.

An Italian research team demonstrated that miR-9 is up-regulated in two types of human immune cells during the pro-inflammatory process and may regulate a NF-kappa-B subunit.

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Russia says its candidate SARS-CoV-2 vaccine has a very high efficacy rate in an initial analysis of clinical trial data, according to the Financial Times.

Wired reports on a microbial analysis of sketches drawn by Leonardo DaVinci.

A new survey explores coronavirus vaccine hesitancy among Black and Latino individuals, the Washington Post reports.

In Nucleic Acids Research this week: the Aging Atlas database, a database of human metagenome-related metadata, and more.