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miRNA

Under the deal, InteRNA’s lentiviral-based miRNA over-expression library will be used in “multi-parametric, high-throughput functional screening assays” to identify the role of individual miRNAs in various cancer pathways. The company hopes to discover novel miRNAs as therapeutic targets.

The patent application, No. 20050261218 and titled "Oligomeric Compounds and Compositions for Use in Modulation [of] Small Non-Coding RNAs," claims methods of inhibiting the liver-specific miRNA miR-122, which has been shown to play a role in hepatitis C virus replication.

While Rockefeller University's Sohail Tavazoie and Ohio State University's Carlo Croce secured the most sizable awards, researchers from the University of Michigan and Harvard University also garnered grants exceeding $500,000.

Under the arrangement, Genetic Technologies will hold the market rights to the three tests in Australia, New Zealand, and Singapore.

University of Pittsburgh School of Medicine researcher Bino John and colleagues reported recently that a so-called unusually small RNA — around 17 nucleotides long — can down-regulate a microRNA target, suggesting a gene-regulation role for the RNA.

Exiqon

OriGene gains products for DNA and RNA purification and multiplex assays for genotyping, microRNA profiling, and transcription factor activity analysis.

Prometheus Laboratories

Some microRNA array vendors say they see no sign in market maturation, and users say there continue to be compelling reasons to add miRNA expression profiling to their research.

Papers of Note: Oct 8, 2009

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RNAi-Related Papers Published September 2009

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Researchers have developed a robotic lab assistant, the Verge reports.

CBC News reports Canada's Supreme Court is to rule on the constitutionality of the country's genetic non-discrimination law today.

The Associated Press reports the World Health Organization is sending experts to China to investigate the animal source of SARS-CoV-2.

In Science this week: atlas of affected cell populations in idiopathic pulmonary fibrosis, and more.