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miRNA

Originally developed in the lab of Phillip Sharp at the Massachusetts Institute of Technology, miRNA sponges are transcripts expressed from strong promoters that contain multiple tandem binding sites to an miRNA of interest.

IP Update: Dec 3, 2009

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USPTO Publishes Seven Patents, Fifteen Patent Applications Related to RNAi

The patent, No. 7,592,441, relates to the human microRNA miR-193b, as well as complementary probes and vectors, the company said.

Under the deal, InteRNA’s lentiviral-based miRNA over-expression library will be used in “multi-parametric, high-throughput functional screening assays” to identify the role of individual miRNAs in various cancer pathways. The company hopes to discover novel miRNAs as therapeutic targets.

The patent application, No. 20050261218 and titled "Oligomeric Compounds and Compositions for Use in Modulation [of] Small Non-Coding RNAs," claims methods of inhibiting the liver-specific miRNA miR-122, which has been shown to play a role in hepatitis C virus replication.

While Rockefeller University's Sohail Tavazoie and Ohio State University's Carlo Croce secured the most sizable awards, researchers from the University of Michigan and Harvard University also garnered grants exceeding $500,000.

Under the arrangement, Genetic Technologies will hold the market rights to the three tests in Australia, New Zealand, and Singapore.

University of Pittsburgh School of Medicine researcher Bino John and colleagues reported recently that a so-called unusually small RNA — around 17 nucleotides long — can down-regulate a microRNA target, suggesting a gene-regulation role for the RNA.

Exiqon

OriGene gains products for DNA and RNA purification and multiplex assays for genotyping, microRNA profiling, and transcription factor activity analysis.

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A German shepherd called Nala has had her genome sequenced.

A coronavirus serology test garners Emergency Use Authorization from the US Food and Drug Administration, but the Los Angeles Times asks: how will tests like that be used?

Certain gene variants in conjunction with a healthy lifestyle may keep brains young, according to New Scientist.

In Science this week: increased CD8 T cell density and increased IFN-gamma response may indicate metastatic prostate cancer patients who will respond to immune checkpoint blockade therapy.