miRNA analysis

By analyzing more than 100 testicular germ cell tumors, investigators characterized mutation, methylation, and other patterns in four histological subtypes of the disease.

Molecular analysis of metastatic CRC in the liver has identified three molecular subtypes that can be coupled with clinical risk scores to inform patient risk.

Given the high yield of miRNA markers they were able to isolate, the researchers believe the approach could be commercialized for routine cancer testing.

This Week in PLOS

In PLOS this week: genomic analysis of honeybee disease, microRNA profiles of people with lupus nephritis, and more.

Researchers have developed a spit-based miRNA test to gauge concussion duration in children, NPR reports.

This Week in PLOS

In PLOS this week: genetic networks involved in antibiotic sensitivity, syphilis pathogen proteome, and more.

Researchers from Northwestern University uncovered five circulating microRNAs that differentiate patients with very high- and low-risk prostate cancer.

This Week in PLOS

In PLOS this week: variants that affect COPD biomarkers, high genetic diversity of Cryptococcus gattii in Brazil, and more.

Genomic, transcriptomic, and methylomic data for more than 150 oligodendroglial tumors uncovered three subgroups within a previously defined low-grade glioma subtype.

The researchers used the tool to look at the role of miRNAs in viral infection, but believe it has potential for studying miRNA in many other contexts.

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The US National Institutes of Health and the Food and Drug Administration have proposed changing gene therapy oversight, the Associated Press reports.

Nature News reports that the Salk Institute has asked for the scope of a gender discrimination lawsuit brought against it to be narrowed.

CNBC reports that the sequencing startup Veritas aims to sequence individuals who fall at extremes.

In PLOS this week: genotyping of indigenous North African goats, program to simulate evolve and resequencing studies, and more.