methylome sequencing

The approach, called cfMeDIP-seq, could distinguish early-stage pancreatic cancer from healthy controls and differentiate several types of cancer.

Stanford University's Michael Snyder found that methylome shifts preceded spikes in his blood glucose levels, suggesting profiling could detect disease.

The team uncovered more than 200 sites in the human genome that were differentially methylated based on parent of origin, including areas linked to disease.

The researchers said the method can help subtype and identify rare cells with clinical implications in neurodevelopment and cancer.

This Week in Nature

In Nature this week: genome-editing to treat hearing loss in mice, juvenile myelomonocytic leukemia subgroups, and more.

Peking University researchers performed single-cell methylome sequencing on preimplantation cells to examine DNA methylation changes during early development.

Investigators identified dozens of neuronal subtypes in mouse and human brain samples using single-cell methylation sequencing, including a new neuronal subtype.

The test, which detects DNA methylation markers, is being developed as an alternative to invasive cystoscopy, the current standard of care.

This Week in PNAS

In PNAS this week: methylation patterns trace cell-free DNA to tissue of origin, cell surface proteome of Ewing sarcoma tumor cells, and more.

The team said their approach may have several applications, including evaluation of cellular response to therapies, and early diagnosis of diseases like cancer.

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Consulting company McKinsey says diagnostics companies will have to combine genomic data analysis, electronic medical records, effective reimbursement strategies, and regulatory compliance in order to win.

A new report has found that researchers in Africa are still heavily dependent on funding from organizations in the US, Europe, and China, Nature News says.

An article in The Atlantic argues that the progress being made in science isn't keeping pace with the money and time being spent on research.

In Science this week: a CRISPR screen identifies sideroflexin 1 as a requisite component of one-carbon metabolism, and more.