Peking University researchers performed single-cell methylome sequencing on preimplantation cells to examine DNA methylation changes during early development.
Investigators identified dozens of neuronal subtypes in mouse and human brain samples using single-cell methylation sequencing, including a new neuronal subtype.
The team said their approach may have several applications, including evaluation of cellular response to therapies, and early diagnosis of diseases like cancer.
The researchers published a proof of principle in Nature Communications of a panel designed to look at epigenetic variation in adipose tissue and are using it to study obesity and metabolic syndromes.
