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methylome sequencing

This Week in PNAS

In PNAS this week: methylation patterns trace cell-free DNA to tissue of origin, cell surface proteome of Ewing sarcoma tumor cells, and more.

The team said their approach may have several applications, including evaluation of cellular response to therapies, and early diagnosis of diseases like cancer.

Researchers have found that normal tissue located near breast tumors exhibits epigenetic changes that may portend predisposition to disease.

University of Liverpool researchers analyzed methylation in the wheat genome to find variations in subgenome-specific methylation.

The researchers published a proof of principle in Nature Communications of a panel designed to look at epigenetic variation in adipose tissue and are using it to study obesity and metabolic syndromes. 

Salk Institute researchers have constructed a human methylome map to uncover tissue-specific variations as well as non-canonical methylation.

NEW YORK (GenomeWeb) – Using epigenetic regulation, the black truffle genome is able to control the transposable elements that make up a large portion of its DNA, an international team of investigators reported in Genome Biology.

Researchers from University College London, have shown that a targeted bisulfite sequencing method using RainDance Technologies' microdroplet PCR system can accurately measure DNA methylation levels at sample sizes as low as 100 nanograms.

Researchers from Dennis Lo's lab at The Chinese University of Hong Kong have adapted their non-invasive prenatal sequencing method for bisulfite sequencing to analyze the methylation status of fetal DNA in maternal plasma samples.

NEW YORK (GenomeWeb News) – An international team led by investigators from Sichuan Agricultural University and BGI-Shenzhen has developed a DNA methylation atlas of pig fat and muscle tissues that is expected to aid studies into the epigenetics of obesity and related conditions.

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In PNAS this week: genes involved in histone deacetylation in Arabidopsis, effects of pathogenic presenilin-1 mutations, and more.

After a study finds DNA from antibiotic-resistant bacteria in Beijing smog, residents there worry, according to the New York Times.

Canada begins its search for a chief government science advisor, Nature News reports.

A company is using facial recognition tools to identify genetic disorders from pictures, Technology Review reports.