methylome sequencing

Investigators identified dozens of neuronal subtypes in mouse and human brain samples using single-cell methylation sequencing, including a new neuronal subtype.

The test, which detects DNA methylation markers, is being developed as an alternative to invasive cystoscopy, the current standard of care.

This Week in PNAS

In PNAS this week: methylation patterns trace cell-free DNA to tissue of origin, cell surface proteome of Ewing sarcoma tumor cells, and more.

The team said their approach may have several applications, including evaluation of cellular response to therapies, and early diagnosis of diseases like cancer.

Researchers have found that normal tissue located near breast tumors exhibits epigenetic changes that may portend predisposition to disease.

University of Liverpool researchers analyzed methylation in the wheat genome to find variations in subgenome-specific methylation.

The researchers published a proof of principle in Nature Communications of a panel designed to look at epigenetic variation in adipose tissue and are using it to study obesity and metabolic syndromes. 

Salk Institute researchers have constructed a human methylome map to uncover tissue-specific variations as well as non-canonical methylation.

NEW YORK (GenomeWeb) – Using epigenetic regulation, the black truffle genome is able to control the transposable elements that make up a large portion of its DNA, an international team of investigators reported in Genome Biology.

Researchers from University College London, have shown that a targeted bisulfite sequencing method using RainDance Technologies' microdroplet PCR system can accurately measure DNA methylation levels at sample sizes as low as 100 nanograms.

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NPR reports that Turkish high school students will no longer study evolution.

Researchers report they sequenced and identified plant species in an "al fresco" laboratory.

An Australian team searches for genetic alterations linked to depression in hopes of developing personalized treatments, the Sydney Morning Herald reports.

In PNAS this week: host contributors to typhoid fever risk, effects of obesity-related variants near TMEM18, and more.