methylome sequencing

The approach, called cfMeDIP-seq, could distinguish early-stage pancreatic cancer from healthy controls and differentiate several types of cancer.

Stanford University's Michael Snyder found that methylome shifts preceded spikes in his blood glucose levels, suggesting profiling could detect disease.

The team uncovered more than 200 sites in the human genome that were differentially methylated based on parent of origin, including areas linked to disease.

Peking University researchers performed single-cell methylome sequencing on preimplantation cells to examine DNA methylation changes during early development.

Investigators identified dozens of neuronal subtypes in mouse and human brain samples using single-cell methylation sequencing, including a new neuronal subtype.

The team said their approach may have several applications, including evaluation of cellular response to therapies, and early diagnosis of diseases like cancer.