Stanford University's Michael Snyder found that methylome shifts preceded spikes in his blood glucose levels, suggesting profiling could detect disease.
The team uncovered more than 200 sites in the human genome that were differentially methylated based on parent of origin, including areas linked to disease.
Peking University researchers performed single-cell methylome sequencing on preimplantation cells to examine DNA methylation changes during early development.
Investigators identified dozens of neuronal subtypes in mouse and human brain samples using single-cell methylation sequencing, including a new neuronal subtype.
The team said their approach may have several applications, including evaluation of cellular response to therapies, and early diagnosis of diseases like cancer.
An international commission is to develop a report on how researchers, clinicians, and regulators should evaluate the clinical applications of human germline genome editing.
In Genome Research this week: repetitive element deletion linked to altered methylation and more in form of muscular dystrophy; human contamination in draft bacterial and archaeal genomes; and more.
