methylome sequencing

The researchers said the method can help subtype and identify rare cells with clinical implications in neurodevelopment and cancer.

This Week in Nature

In Nature this week: genome-editing to treat hearing loss in mice, juvenile myelomonocytic leukemia subgroups, and more.

Peking University researchers performed single-cell methylome sequencing on preimplantation cells to examine DNA methylation changes during early development.

Investigators identified dozens of neuronal subtypes in mouse and human brain samples using single-cell methylation sequencing, including a new neuronal subtype.

The test, which detects DNA methylation markers, is being developed as an alternative to invasive cystoscopy, the current standard of care.

This Week in PNAS

In PNAS this week: methylation patterns trace cell-free DNA to tissue of origin, cell surface proteome of Ewing sarcoma tumor cells, and more.

The team said their approach may have several applications, including evaluation of cellular response to therapies, and early diagnosis of diseases like cancer.

Researchers have found that normal tissue located near breast tumors exhibits epigenetic changes that may portend predisposition to disease.

University of Liverpool researchers analyzed methylation in the wheat genome to find variations in subgenome-specific methylation.

The researchers published a proof of principle in Nature Communications of a panel designed to look at epigenetic variation in adipose tissue and are using it to study obesity and metabolic syndromes. 

Pages

The UK's Human Fertility and Embryology Authority calls for consumer genetic testing companies to warn customers that testing could uncover family secrets, according to the Guardian.

The New York Times reports that United Nations delegates have been discussing how to govern the genetic resources of the deep sea.

Researchers have transplanted edited cells into mice that appear to combat cocaine addiction, New Scientist reports.

In PNAS this week: analysis of proteolytic enzymes secreted by circulating tumor cells, phylogenetic study of Fv1 evolution, and more.