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methylation analysis

In an epigenome-wide association study of depression, the researchers tied DNA methylation to disease symptoms and suggested a role for axon guidance disruption.

Patients whose tumors had methylated MGMT promoters were more likely to survive than those that did not after combination treatment with radiotherapy and temozolomide.

A large meta-analysis and functional genomic assessment of a risky HLA haplotype uncovered hypomethylation that alters immune-related expression at the locus.

Researchers examined DNA methylation and chromatin accessibility in preimplantation embryos using single-cell chromatin overall omic-scale landscape sequencing.

By analyzing more than 100 testicular germ cell tumors, investigators characterized mutation, methylation, and other patterns in four histological subtypes of the disease.

Researchers found that individuals with unexplained neurodevelopmental disorders and congenital anomalies had an enrichment of de novo epivariations.

With genome-wide association study data, researchers saw enrichment for schizophrenia-linked SNPs in human-specific differentially methylated regions.

In Genome Research this week, mismatch repair deficiency in C. elegans, retracing transcriptions start site evolution in the human genome, and more. 

The team found that colorectal cancer cells experience substantial increases in somatic mutations compared to normal colorectal cells.

With integrated data for thousands of TCGA tumors, teams explored cancer subtypes, searched for prognostic insights, began mapping immune cell interactions, and more.

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Mainichi reports that 43 percent of Japanese individuals said they did not want to eat agricultural products that had been modified using gene-editing tools.

Two US Department of Agriculture research departments are moving to the Kansas City area, according to the Washington Post.

Slate's Jane Hu compares some at-home genetic tests to astrology.

In PLOS this week: analysis of polygenic risk scores for skin cancer, chronic pain GWAS, and more.