MALDI | GenomeWeb

MALDI

Multi-omics, mass spec-based imaging, and cardiovascular biomarkers received extra attention at MSACL US while small molecules continue to drive the field.

Mass spec instrumentation showed solid growth in Q3, with particular strength in academic and government markets.

While LC-MS/MS workflows using triple quadrupoles and, more recently, Q-TOF and Q-Exactive instruments, have typically dominated discussion of mass spec-based protein quantitation, MALDI mass spec has recently emerged as a potential alternative for such applications.

By a GenomeWeb staff reporter
NEW YORK (GenomeWeb News) – Shimadzu and Sony DADC have extended a collaboration to develop application-specific, individually barcoded, disposable MALDI targets for regulated and non-regulated markets.

Included are a method for analyzing glycoproteins; a method of direct protein identification using MALDI mass spectrometry; and protein biomarkers for cancer sensitivity.

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The technique is based on a MALDI triple-quadrupole platform and exploits the selective multiple-reaction monitoring transition features of the instrument to circumvent problems resulting from interference that can plague existing methods.

Three German labs have accredited the MALDI Biotyper.

A new agreement will expand Biotyper use in Germany and covers two labs in Poland.

Researchers in the Netherlands have identified 44 protein biomarkers that appear repeatedly in 2D gel electrophoresis-based disease biomarker studies and have linked them to cellular stress response, adding "in future proteomic studies, more profound approaches should be applied to look beyond these proteins to find specific biomarkers."

In Science this week: genetic target for urothelial bladder cancer treatment, and more.

At the Conversation, the University of Oxford's Michael Macklay writes that learning genetic risk of disease is a personal decision.

Two dozen scientific organizations have endorsed the March for Science, according to ScienceInsider.

Researchers in Japan describe a chimpanzee with a chromosomal abnormality similar to human Down syndrome, Mashable reports.