A short pyknon motif on the lncRNA N-BLR appears to mediate its effect on cells' ability to metastasize and invade in colorectal cancer, researchers found.
The firm's recent funding round will support its CLIA-certified laboratory that opened last year and the launch of its first RNA-based diagnostic test.
In PLOS this week: RNA-directed DNA methylation in Arabidopsis, TLR5 variants linked to melioidosis survival, and more.
In PLOS this week: loci linked to body mass index measurements, long non-coding RNA expression and urothelial carcinoma prognosis, and more.
The FANTOM consortium generated an atlas of nearly 30,000 human long non-coding RNAs that suggests more than 19,000 of them are functional.
In Nucleic Acids Research this week: nanopore sequencing workflow to detect antibiotic resistance in gut microbes, TSSPlant tool, and more.
Researchers at UCSF used CRISPR interference to knockdown lncRNA transcripts, then assayed for cell growth to get the final list of almost 500.
In Science this week: study of the functions of long non-coding RNAs, and more.
In PNAS this week: TP53-linked lncRNA inactivated in some cancers, genetic architecture in Arabidopsis hybrids, and more.
In Nature this week: Cardamine hirsute reference genome, CRISPR screen for lncRNAs, and more.
Two new Reproducibility Project: Cancer Biology studies have largely reproduced the original findings, ScienceInsider reports.
DNA fingerprinting could catch some sample mix-ups at pathology labs, the New York Times says.
A Maryland police department has turned to DNA phenotyping to develop a suspect sketch, WJLA reports.
In Cell this week: DNA methylation and T cell exhaustion, longevity in C. elegans, and more.