LNA | GenomeWeb


Qiagen has submitted an offer to buy all of Exiqon's shares for DKK18 each, for a total aggregate purchase price of DKK683 million ($103.5 million).

Roche is moving forward with Santaris' LNA-based antagonist of HIF-1 alpha, but has not decided on the future of a Phase II microRNA-target HCV drug candidate.

This story has been updated to include additional comment from Roche.

A team led by researchers from Massachusetts General Hospital and Santaris Pharma this week published new data showing that inhibition of the microRNA-33 family using short locked nucleic acids could impact cholesterol levels in non-human primates without triggering any adverse e

Santaris Pharma said this week that partner Enzon has returned the rights to all of the data and intellectual property related to the locked nucleic acid drugs the companies were developing under a long-term partnership in cancer.

A team from the University of Potsdam in Germany has combined wild-type blocking PCR using locked nucleic acids with high-resolution melting analysis to detect DNA mutations of unknown type and position in a background of up to 10,000-fold wild-type DNA.

Rana Therapeutics, a developer of gene-activation therapeutics, has inked a deal to use Santaris Pharma’s locked nucleic acid technology to develop drugs against up to 10 proprietary targets.

Santaris Pharma this week announced that it has formed a world-wide drug discovery alliance with Bristol-Myers Squibb.

Pfizer last week took steps to head off a court hearing with Isis Pharmaceuticals, arguing that it has met its obligations to produce research documents in its possession relevant to Isis’ ongoing patent-infringement lawsuit against Santaris Pharma.

Santaris Pharma announced this week that the US Patent and Trademark Office has issued a inter partes re-examination certificate for a US patent held by the company and covering locked nucleic acids.


In PNAS this week: miR-515 levels higher in women with preeclampsia, horizontal gene transfer in parasitic plants, and more.

A cancer researcher retracts 19 articles from one journal for image manipulation, according to Retraction Watch.

Precision medicine has to consider context in addition to genetic mutations in cancer treatment, Medscape reports.

Genomics may help the Cavendish banana from succumbing to fungal infections, a trio of researchers writes at the Conversation.