linkage analysis Several Causal Variants Found at Genetic Loci Influencing Gene Expression in Humans With a massively parallel reporter assay (MPRA) approach, investigators found causal variants at loci impacting the expression of hundreds of genes. COVID-19 Genetic Risk Factor Passed Down From Neanderthals, Study Finds A gene cluster inherited by modern humans from Neanderthals was recently identified as a risk locus for respiratory failure following SARS-CoV-2 infection. Numerous Variants in Single Gene Linked to Decreased Blood Oxygen During Sleep The researchers combined a linkage analysis followed by whole-genome sequencing data to link the DLC1 gene to blood oxygen levels during sleep. New Mosquito Genome Expected to Serve as Infectious Disease Resource With long-read sequencing, mapping, and other approaches, researchers assembled a high-quality genome for Aedes aegypti, a notorious infectious disease vector. Alzheimer's Disease Study Finds Potentially Protective Genetic Variants Based on the results, RAB10 could be a promising therapeutic target for the prevention of Alzheimer's. May 22, 2017 Computational Model Offers Clues to Missing Heritability for Complex Human Traits Feb 27, 2017 Mutations in DCC Gene Linked to Multiple Brain Malformation Conditions Mar 30, 2016 Familial Autoinflammatory Disease Traced to Missense Mutation in MEFV Feb 4, 2016 Family Study Uncovers Mutation Involved in Rare Vibration Allergy Dec 28, 2015 Harvard, Peking University Team Combines NGS, Linkage Analysis to Detect Aneuploidy, SNVs for PGD Premium Jul 9, 2015 Team Pins Susceptibility to Innocuous Bacteria, Fungi on Mutations in Single Gene Jun 19, 2015 Genomic Analysis IDs New Gene Related to Immunodeficiency May 15, 2014 Linkage Analysis, Exome Sequencing Uncover Novel Variants Associated with Metabolic Syndrome May 28, 2013 Multiple Variants within Signaling Pathway Linked to Schizophrenia Oct 5, 2010 Linkage Analysis Combined with Targeted Sequencing Locates Disease Gene in Microcephaly Premium Breaking News SARS-CoV-2 Mutational Signature Associated With Mutagenic Antiviral Drug Biocartis Restructures Balance Sheet as H1 2023 Revenues Rise 12 Percent Rare Kidney Cancer Genomic Analysis Reveals Potential Target, Suggests Treatment SEC Concludes CareDx Investigation, Recommends No Enforcement Action Streck Quality Controls for DiaSorin's Luminex Sepsis Tests Receive FDA Clearance The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.