linkage analysis Several Causal Variants Found at Genetic Loci Influencing Gene Expression in Humans With a massively parallel reporter assay (MPRA) approach, investigators found causal variants at loci impacting the expression of hundreds of genes. COVID-19 Genetic Risk Factor Passed Down From Neanderthals, Study Finds A gene cluster inherited by modern humans from Neanderthals was recently identified as a risk locus for respiratory failure following SARS-CoV-2 infection. Numerous Variants in Single Gene Linked to Decreased Blood Oxygen During Sleep The researchers combined a linkage analysis followed by whole-genome sequencing data to link the DLC1 gene to blood oxygen levels during sleep. New Mosquito Genome Expected to Serve as Infectious Disease Resource With long-read sequencing, mapping, and other approaches, researchers assembled a high-quality genome for Aedes aegypti, a notorious infectious disease vector. Alzheimer's Disease Study Finds Potentially Protective Genetic Variants Based on the results, RAB10 could be a promising therapeutic target for the prevention of Alzheimer's. May 22, 2017 Computational Model Offers Clues to Missing Heritability for Complex Human Traits Feb 27, 2017 Mutations in DCC Gene Linked to Multiple Brain Malformation Conditions Mar 30, 2016 Familial Autoinflammatory Disease Traced to Missense Mutation in MEFV Feb 4, 2016 Family Study Uncovers Mutation Involved in Rare Vibration Allergy Dec 28, 2015 Harvard, Peking University Team Combines NGS, Linkage Analysis to Detect Aneuploidy, SNVs for PGD Premium Jul 9, 2015 Team Pins Susceptibility to Innocuous Bacteria, Fungi on Mutations in Single Gene Jun 19, 2015 Genomic Analysis IDs New Gene Related to Immunodeficiency May 15, 2014 Linkage Analysis, Exome Sequencing Uncover Novel Variants Associated with Metabolic Syndrome May 28, 2013 Multiple Variants within Signaling Pathway Linked to Schizophrenia Oct 5, 2010 Linkage Analysis Combined with Targeted Sequencing Locates Disease Gene in Microcephaly Premium Breaking News European Commission Outlines Intended Restorative Measures for Blocked Illumina-Grail Deal Cross-Trait Meta-Analysis Explores Potential Pleiotropy Across Psychiatric Conditions Bactobio Raises £6M in Private Financing Top Five Articles on GenomeWeb Last Week: Amazon Omics, Ashkenazi Jewish Population History, More AnPac Bio to Raise $5M in Private Placement The Scan Team Tracks Down Potential Blood Plasma Markers Linked to Heart Failure in Atrial Fibrillation Patients Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases. Study Points to Synonymous Mutation Effects on E. Coli Enzyme Activity Researchers in Nature Chemistry saw signs of enzyme activity shifts in the presence of synonymous mutations in a multiscale modeling analysis of three Escherichia coli genes. Team Outlines Paternal Sample-Free Single-Gene Approach for Non-Invasive Prenatal Screening With data for nearly 9,200 pregnant individuals, researchers in Genetics in Medicine demonstrate the feasibility of their carrier screening and reflex single-gene non-invasive prenatal screening approach. Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.