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LC-MS/MS

In Nature this week: sister-chromatid-sensitive chromosome conformation capture approach, and more.

A method called microbiome-derived metabolism screening highlighted drug alterations after exposure to personalized gut microbe collections.

Gladstone Institutes researchers will use proteomic, genomic, and gene-altering approaches to investigate apoe4 toxicity as part of a five-year project.

Ring Materials

Discover magazine writes that paleoproteomics is increasing being used in archaeology, paleoanthropology, and paleontology, including a recent study of a 6,000-year-old ring. 

With genomic and proteomic profiles for more than 100 colon cancer cases, researchers identified drug targets, treatment resistance insights, potential cancer drivers, and more.

The analysis uncovered established subtypes and added new classifications, while also identifying a potential new treatment target.

A multi-omic analysis implicated a handful of transcription factors, along with genes and regulatory RNAs down- and upstream of them, in metastatic colorectal cancer.

Researchers were able to identify 40 tumor-specific antigens within two mouse cancer cell lines and seven human primary tumors using this approach.

Myrmecia gulosa

Researchers identified a diverse toxin gene superfamily using venom-related tissue transcripts and venom peptides from the giant red bull ant.

Using proteomic and genetic approaches, researchers identified a histone mark called lysine benzoylation that appears to be enhanced by exposure to sodium benzoate.

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Kaiser Health News reports San Francisco and Alameda counties in California are no longer using Verily Life Sciences' COVID-19 testing program.

The New York Times reports that developers in New York City are increasingly interested in life science spaces.

A UK study has found that antibodies against SARS-CoV-2 may decline over time, Reuters reports.

In PNAS this week: genetic and epigenetic variation in individuals with diabetic kidney disease, spontaneous genetic alterations in Saccharomyces cerevisiae, and more.