laser capture microdissection
Human Brain Circular RNAs Linked to Neuron Type, Neuropsychiatric Conditions
Using deep RNA sequencing, researchers identified cell type- and disease-related circRNAs in brain samples from individuals with or without Parkinson’s or Alzheimer’s disease.
Max Planck Team Develops Workflow Combining Single-Cell Imaging With Deep Proteomic Profiling
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Called deep visual proteomics, the approach allows for the characterization of thousands of proteins in small numbers of cells while retaining spatial information.
Normal Endometrial Glands Harbor Cancer-Associated Mutations, Study Finds
The sequencing-based analysis also found that some of these cancer-linked alterations in endometrial glands may occur early in life.
Gene Expression Study of Brain Cell Layer Finds New Schizophrenia Risk Loci
The analysis of a hippocampus cell layer uncovered genetic loci associated with schizophrenia risk, including two that may represent drug targets.
The method uses hydrogel encapsulation, which mimics a tissue sample, in order to allow circulating tumor cell isolation and extraction through laser dissection.