isobaric tagging

The reagents are intended for use in a recently developed workflow designed to address the precursor interference issue that has troubled the labeling method.

At the National Center for Quantitative Biology of Complex Systems, scientists hope mass spec will drive new biological questions and vice versa.

Writing in MCP, the researchers provided a survey of techniques for biologists interested in using multiplexed quantitative proteomics in their research.

The reagents, which use combinations of reporter ions, could allow for multiplexes of up to 28 samples, more than double the capacity of existing tags.

A team of Roche researchers has developed a five-plex SILAC method for quantifying the dynamics of tyrosine phosphorylation.

Proteome Sciences said this week that it has signed an agreement with Thermo Fisher Scientific providing access to patents related to its Tandem Mass Tags isobaric tagging reagents in exchange for cash and a no-cost lease from Thermo Fisher for mass spectrometry equipment.

This story has been updated to correct an earlier version that identified Steven Gygi as an MIT researcher. He is a researcher at Harvard University.

Researchers from the University of Wisconsin-Madison have characterized the mitochondrial acetylome, finding significant changes in protein acetylation in response to calorie restriction and activity of the protein deacetylase SIRT3.

Though many details have yet to be worked out, the draft deal for the UK's withdrawal from the EU is giving researchers some hints for what they can expect, Nature News says.

DNA testing has solved a 100-year-old mystery contained in the skull and teeth samples of a now-extinct monkey that once inhabited Jamaica, Gizmodo reports.

As the UN ponders a ban on gene drives, one malaria researcher says there are less dramatic ways to fight the disease in Africa than unleashing GM mosquitoes on a whole continent.

In Nature this week: an improved reference genome of the Aedes aegypti mosquito, genomes of four species of truffles, and more.