isobaric tagging

The reagents are intended for use in a recently developed workflow designed to address the precursor interference issue that has troubled the labeling method.

At the National Center for Quantitative Biology of Complex Systems, scientists hope mass spec will drive new biological questions and vice versa.

Writing in MCP, the researchers provided a survey of techniques for biologists interested in using multiplexed quantitative proteomics in their research.

The reagents, which use combinations of reporter ions, could allow for multiplexes of up to 28 samples, more than double the capacity of existing tags.

A team of Roche researchers has developed a five-plex SILAC method for quantifying the dynamics of tyrosine phosphorylation.

Proteome Sciences said this week that it has signed an agreement with Thermo Fisher Scientific providing access to patents related to its Tandem Mass Tags isobaric tagging reagents in exchange for cash and a no-cost lease from Thermo Fisher for mass spectrometry equipment.

This story has been updated to correct an earlier version that identified Steven Gygi as an MIT researcher. He is a researcher at Harvard University.

Researchers from the University of Wisconsin-Madison have characterized the mitochondrial acetylome, finding significant changes in protein acetylation in response to calorie restriction and activity of the protein deacetylase SIRT3.

The New York Times and ProPublica look into the close relationship between a startup and Memorial Sloan Kettering Cancer Center.

Yahoo News reports millions of dollars are being transferred from NIH, CDC, and other programs to pay for the housing of detained undocumented immigrant children.

In Science this week: in vitro generation of human reproductive cells, and more.

Researchers gave a handful of octopuses MDMA to find that they too act more social on the drug, Gizmodo reports.