immune repertoire sequencing Single-Cell MRD Assay Helps Characterize Cells Surviving Acute Myeloid Leukemia Therapy Researchers came up with a single-cell DNA sequencing and immunophenotyping assay for identifying and characterizing AML clones that persist after treatment. Adaptive Biotechnologies Sees ClonoSeq Test Volume Grow, Reports 12 Percent Revenue Growth for Q2 During the quarter, the Seattle-based company reported total revenues of $48.9 million, beating analysts' consensus estimate of $44.9 million. Adaptive Biotechnologies Q1 Revenues Decline 3 Percent The Seattle-based immune sequencing firm booked $37.6 million in revenues, with 43 percent from immune medicine and 57 percent from its minimal residual disease business. Wellcome Sanger's Dandelion Pipeline Updated for Single-Cell Adaptive Immune Receptor Analysis Premium The Dandelion bioinformatics method now includes T-cell receptor-based "pseudotime trajectory analysis" to support better understanding of single-cell lymphocyte biology. Adaptive Biotechnologies, Takeda Partner to Develop Treatments for Lymphoid Malignancies The multiyear collaboration will use Adaptive's ClonoSeq assay to measure minimal residual disease status as an endpoint for Takeda’s clinical trials. Feb 15, 2023 Adaptive Biotechnologies Lays out Strategy to Drive ClonoSeq Adoption Jan 6, 2023 Immune Signatures Outperform TILs for HER2-Positive Breast Cancer Prognoses Jan 5, 2023 T Cell Receptor Repertoire Analysis Points to Potential Tuberculosis Vaccine Targets Nov 4, 2022 Adaptive Bio Narrows 2022 Revenue Guidance, Outlines Financial Expectations Aug 4, 2022 Adaptive Biotechnologies Halts T-Detect Commercialization, Reports 13 Percent Q2 Revenue Growth Premium Jul 28, 2022 Adaptive Biotech's ClonoSeq Gets Expanded Medicare Coverage For B-Cell Lymphoma May 5, 2022 Adaptive Biotechnologies Making Inroads in MRD, Immune Medicine Businesses Premium May 4, 2022 Adaptive Biotechnologies Q1 Revenues Rise Slightly in Q1 Apr 26, 2022 Evaxion Biotech Adopts Personalis Immune Profiling Platform for Melanoma Immunotherapy Trial Mar 3, 2022 Adaptive Biotechnologies Makes Progress Toward T-Cell Assay for Inflammatory Bowel Disease Premium Feb 16, 2022 Adaptive Biotechnologies to Focus on Immune Medicine, Minimal Residual Disease Testing Businesses Premium Feb 15, 2022 Adaptive Biotechnologies Revenues Rise 26 Percent in Q4, 57 Percent in 2021 Dec 17, 2021 A*STAR Wins $2M Chan Zuckerberg Initiative Grant to Advance Asian Immune Cell Atlas Nov 16, 2021 Cancer Genomic Analysis Reveals Distinct Features in Tumors From Patients Under 50 Years Old Nov 3, 2021 Adaptive Biotechnologies Q3 Revenues Rise 50 Percent Aug 4, 2021 Adaptive Biotechnologies Q2 Revenues Jump 83 Percent Jul 9, 2021 Integrated Tumor, Microbiome Features Influence Immunotherapy Combo Effects in Advanced Melanoma Jun 22, 2021 China's Singleron Biotechnologies Pushes Single-Cell RNA-seq Into Clinical, Translational Studies Premium May 6, 2021 Adaptive Biotech Touts Progress Toward Lyme and Gastrointestinal Disease Diagnostics Premium May 5, 2021 Adaptive Biotechnologies Q1 Revenues up 84 Percent, Beat Analyst Estimates Load More Breaking News Natera Submits Signatera Bladder Cancer PMA Module to FDA FDA Grants Emergency Use Authorizations for POC COVID Tests from Tangen Biosciences, SD Biosensor Top Five Articles on GenomeWeb Last Week: FDA Proposal for LDT Oversight, Adela $48M Financing, More FDA Grants Marketing Authorization for Invitae Hereditary Cancer DNA Sequencing Test Compact Gene Editing Enzyme May Improve Success Rates of Gene Therapies The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.