hybridization

Researchers used the approach to develop an assay to detect above-threshold triplet repeats in Huntington's disease, but also highlight a variety of other applications.

The British molecular genetics company recently announced a menu update for its SureSeq myPanel NGS Custom Cancer Panel offering.

The firm envisions applying its new PlexSet technology to the upper end of multiplex gene expression analysis as well as CRISPR validation applications.

The new study in NEJM describes six families that share a disorder caused by mutations in IKAROS, a protein that plays a role in immune cell development. 

Fred Hutch researchers report that analysis of one metastatic prostate tumor sample captures most of the variation in an individual's various metastases.

In early experiments, the method's raw single pass error rate was approximately 2 percent for a single target and up to 4 percent for a mixture of 10 targets. 

The chemistry will be single-molecule, based on hybridization, and will not require amplification, enzymes, or library prep, the firm said.

Reveal will use Affy's ViewRNA in situ hybridization products in combination with its image-analysis software for tissue staining, imaging, and quantification.

The authors have plans to turn the technology into a kit for sequencing panels to be developed by their startup firm, Searna. 

The company will focus on gaining customers for its custom and pre-defined hybrid capture kits first in Southern California, and then across the US.

Pages

Using DNA to sketch crime victims might not be a great idea, the NYTimes says.

Science has its own problem with sexual harassment. What do we do with the research these abusers produce, Wired asks.

Senate Republicans led by Senator Rand Paul (R-KY) are trying to change how the government funds basic research, reports ScienceInsider.

In Science this week: combining genomics and ecology to better understand the effects of natural selection on evolution, and more.