hybridization | GenomeWeb


The new study in NEJM describes six families that share a disorder caused by mutations in IKAROS, a protein that plays a role in immune cell development. 

Fred Hutch researchers report that analysis of one metastatic prostate tumor sample captures most of the variation in an individual's various metastases.

In early experiments, the method's raw single pass error rate was approximately 2 percent for a single target and up to 4 percent for a mixture of 10 targets. 

The chemistry will be single-molecule, based on hybridization, and will not require amplification, enzymes, or library prep, the firm said.

Reveal will use Affy's ViewRNA in situ hybridization products in combination with its image-analysis software for tissue staining, imaging, and quantification.

The authors have plans to turn the technology into a kit for sequencing panels to be developed by their startup firm, Searna. 

The company will focus on gaining customers for its custom and pre-defined hybrid capture kits first in Southern California, and then across the US.

The test uses mitochondrial DNA hybridization arrays to detect up to 21 animals that are ingredients or contaminants in food for humans, pets, and livestock.

A new study in Nature Chemistry illustrates why PCR, NGS, and microarray firms are interested in incorporating the startup's workflow into their products.

The company is using a $3 million, three-year grant to clinically validate the test, which it hopes will be the first of its kind approved by the FDA.


In PNAS this week: miR-515 levels higher in women with preeclampsia, horizontal gene transfer in parasitic plants, and more.

A cancer researcher retracts 19 articles from one journal for image manipulation, according to Retraction Watch.

Precision medicine has to consider context in addition to genetic mutations in cancer treatment, Medscape reports.

Genomics may help the Cavendish banana from succumbing to fungal infections, a trio of researchers writes at the Conversation.