high-throughput screening

The researchers identified genes that specifically extend the lifespan of neurons and found genes that increase the number of neurites in the brain.

Researchers focused in on strong candidate genes in schizophrenia with brain anatomy, brain activity, and behavioral screens on a large set of zebrafish mutants.

The team's Pro-Code system enabled simultaneous high-dimensional protein-level phenotyping of hundreds of genes with single-cell resolution.

Researchers used CRISPR-Cas9 screening assays in mouse and human cells to track down point mutations in the PARP1 gene that boost resistance to PARP inhibitor drugs.

Using a synthetic genetic screen, investigators identified potential drug targets and tumor suppressors in colorectal cancer xenograft models.

The gene-gene interactions research could lead to new therapies targeting cells with particular mutations, or combinations of targeted therapies.