Researchers used CRISPR-Cas9 screening assays in mouse and human cells to track down point mutations in the PARP1 gene that boost resistance to PARP inhibitor drugs.
Saturation mutagenesis of the human malaria parasite Plasmodium falciparum identified almost 2,700 essential genes during the blood stage of infection.
Using a synthetic genetic screen, investigators identified potential drug targets and tumor suppressors in colorectal cancer xenograft models.
Investigators developed a pooled method for simultaneously sequencing RNA in bulk sets of samples being profiled by high-throughput screening assays.
The program will provide two young scientists with funding for independent research as well as resources to help them commercialize their technology.
The gene-gene interactions research could lead to new therapies targeting cells with particular mutations, or combinations of targeted therapies.
A new user-friendly software tool is helping Rory Johnson of the University of Bern to do genome-wide screening of lncRNA function by deleting promoters.
Researchers at UCSF used CRISPR interference to knockdown lncRNA transcripts, then assayed for cell growth to get the final list of almost 500.
Using two guide RNAs to excise chunks of the genome, an international team identified lncRNAs essential and inhibitory to human cancer cell line proliferation.
A team of Austrian scientists used their new screening method to investigate genes and transcription factors regulating T cell receptor signaling.
NPR reports on Human Cell Atlas Consortium's effort to catalog all the different cell types within the human body.
The Union of Concerned Scientists surveyed US government scientists about Trump Administration policies and more, Science reports.
National Geographic reports that marine mammals have lost a gene that could make them more susceptible to organophosphate damage.
In PNAS this week: history and genetic diversity of the scarlet macaw, approach for predicting human flu virus evolution, and more.