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The team also found that the proportion of infected people didn't change substantially during the screening period, consistent with beneficial containment.
The screen, which multiplexes Cas9 and Cas12a, could be used for functional analysis of large genomic regions in mammalian cells, the researchers said.
The screening platform, which uses the Cas13 nuclease to target RNA instead of DNA, can be used to design guide RNAs for CRISPR research.
Called Theta, Single Technologies' platform relies on automated fluidics and single molecule-sensitive imaging to improve sequencing throughput.
Two recent CRISPR-Cas9 viability screens in cancer cell lines were concordant across multiple metrics despite significant differences in experimental protocols.
In Science this week: approach to measure microRNA targeting efficiency, strategy to conduct high-throughput chemical screens at single-cell resolution, and more.
The new method, called sci-Plex, combines nuclear hashing and improved single-cell combinatorial indexing RNA-seq to profile the transcriptional response of single cells.
The researchers identified genes that specifically extend the lifespan of neurons and found genes that increase the number of neurites in the brain.
The researchers created a resource of cancer dependencies and developed a framework to prioritize existing cancer drug targets and suggest new ones.
Researchers focused in on strong candidate genes in schizophrenia with brain anatomy, brain activity, and behavioral screens on a large set of zebrafish mutants.
A study suggests people with the ApoE e4 genotype may be more likely to have severe COVID-19 than those with other genotypes, the Guardian says.
New analyses indicate female researchers are publishing less during the coronavirus pandemic than male researchers, according to Nature News.
Direct-to-consumer genetic testing companies are searching for a genetic reason for why some people, but not others, become gravely ill with COVID-19, the Detroit Free Press reports.
In PNAS this week: forward genetics-base analysis of retinal development, interactions of T cell receptors with neoantigens in colorectal cancer, and more.