Researchers used CRISPR-Cas9 screening assays in mouse and human cells to track down point mutations in the PARP1 gene that boost resistance to PARP inhibitor drugs.
Saturation mutagenesis of the human malaria parasite Plasmodium falciparum identified almost 2,700 essential genes during the blood stage of infection.
Using a synthetic genetic screen, investigators identified potential drug targets and tumor suppressors in colorectal cancer xenograft models.
Investigators developed a pooled method for simultaneously sequencing RNA in bulk sets of samples being profiled by high-throughput screening assays.
The program will provide two young scientists with funding for independent research as well as resources to help them commercialize their technology.
The gene-gene interactions research could lead to new therapies targeting cells with particular mutations, or combinations of targeted therapies.
A new user-friendly software tool is helping Rory Johnson of the University of Bern to do genome-wide screening of lncRNA function by deleting promoters.
Researchers at UCSF used CRISPR interference to knockdown lncRNA transcripts, then assayed for cell growth to get the final list of almost 500.
Using two guide RNAs to excise chunks of the genome, an international team identified lncRNAs essential and inhibitory to human cancer cell line proliferation.
A team of Austrian scientists used their new screening method to investigate genes and transcription factors regulating T cell receptor signaling.
Science speaks with the University of Michigan's Jedidiah Carlson, who has tracked population genetic discussions at white nationalist sites.
Gene therapies could qualify for a faster US Food and Drug Administration approval process, according to Stat News.
NPR reports that the US House of Representatives has passed a bill to enable terminally ill patients access to experimental drugs.
In Genome Research this week: inversion variants mapped in human, non-human primate genomes; transcriptome profiling of maize, sorghum; and more.