GWAS

In healthcare, Cloudera has evolved from mostly supporting downstream variant stores to being a centerpiece of the shift to GATK4.

A genome-wide association study meta-analysis found bipolar disorder patients with poor response to lithium have more polygenic risk factors for schizophrenia.

A genome-wide association meta-analysis involving hundreds of thousands of individuals led to 130 new and known risk variants linked to all three allergic conditions.

Using genome-wide association and targeted sequencing approaches, research teams continue to tally up genetic contributors and candidate genes in breast cancer.

Based on genotypes for people with or without food allergies, investigators saw loci near immune, inflammation, and epithelial genes.

In a wide-ranging discussion, the two leaders touched upon vaccine development, infant mortality, US education, research funding, machine learning, and precision medicine.

A Johns Hopkins team reported its finding in JAMA Cardiology, backed by SNP array data from 21,870 participants culled from several large cardiovascular studies.

The researchers searched for schizophrenia risk loci using cohorts of both Chinese and European ancestry.

Variants in and around inflammation-related gene CD53 were linked to TB in older Thai individuals infected with certain Mycobacterium tuberculosis lineages.

A new genome-wide association study involving data from thousands of 23andMe customers implicated six loci in gestational duration or preterm birth risk.

Pages

The US Food and Drug Administration has new guidelines that enable some gene and cell therapies to undergo expedited review, according to the New York Times.

Using gene drives to control invasive species might be too risky, an initial advocate of the approach says.

Researchers have grown tumors in 3D cell cultures to better understand cancer, the Economist reports.

In Science this week: intellectual property experts argue patent battles such as the one over CRISPR are wasteful, and more.