A large genome-wide association in breast cancer cases and controls from Japan led to common variants linked to disease risk at two new and nine known risk loci.
Genotypes for more than 12,000 individuals from the Americas revealed contributions from European colonization, the Atlantic slave trade, and other migrations.
Researchers documented population structure, ancestry patterns, trait associations, and more with variants found in the genomes of more than 6,400 Ugandans.
The search uncovered two post-traumatic stress disorder loci in Europeans and a third in individuals with African ancestry, highlighting immune- and brain-related genes.
A genomic analysis of ancient and modern samples revealed population clusters and ancestral contributions stemming from historical migrations and admixture events.
Results from some 4,200 GWAS suggest a significant subset of genetic loci contribute to multiple complex traits, though the type of overlap further varied at the gene and SNP levels.
In European American military veterans, the study led to several genetic loci with ties to the severity of a core PTSD symptom known as reexperiencing.
In Science this week: approach to measure microRNA targeting efficiency, strategy to conduct high-throughput chemical screens at single-cell resolution, and more.
