genome assembly
Comparison of 239 Primate Genomes Reveals Conserved Regulatory Sequences
By aligning and comparing whole-genome sequences for 239 species, researchers identified regulatory elements that have become constrained specifically in primates.
Researchers from China and the US have produced the first broad benchmark of genomic and metagenomic assemblers specifically for PacBio HiFi sequence data.
Pangenome Reference Provides 'Inclusive' View of the Human Genome
The new draft contains phased, diploid assemblies from 47 genetically diverse individuals and could have major implications for personalized medicine.
By augmenting PacBio HiFi sequencing with Oxford Nanopore ultralong reads, Verkko produced complete assemblies of 20 of the 46 human chromosomes.
Human Pangenome Reference Consortium Develops 'Semi-Automated' Diploid Genome Assembly Method
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An assembly approach using the graph-based hifiasm algorithm with PacBio HiFi long reads from a sequenced trio was the "clear winner," senior author Erich Jarvis said.