Gene Editing & Gene Silencing | GenomeWeb

Gene Silencing/Gene Editing

The company emerged from stealth mode this month and traces roots to both rocket maker SpaceX and the shuttered sequencing company Halcyon Molecular. 

The new method takes expressed mRNA and turns it into guide sequences for CRISPR/Cas9 knockout screening when bioinformatics-based design isn't an option.

The contract research organization said it has already used CRISPR/Cas9 editing in several customer projects and also plans to use it for internal R&D.

Scientists introduced an indel to a promoter region to mimic a benign, naturally-occurring mutation that activated fetal hemoglobin production.

A new study suggests CRISPR/Cas9-based gene activation can manipulate particular epigenomic patterns found in differentiated cells. 

Protein having nuclease activity, fusion protein and uses thereof
Construction of new variants of dextransucrase DSR-S by genetic engineering
Insect resistant cotton plants and methods for identifying same
Genomic plant sequences and uses thereof
Photocleavable oligonucleotide and uses thereof
Eukaryotic expression system and use thereof

In Nature this week: SNP reference panel from the Haplotype Reference Consortium, and more.

Halloran Consulting's Laurie Halloran lists at Stat News the mistakes she sees startup companies make when pursuing a clinical trial.

MIT researchers are using bees to collect and visualize urban microbiome samples, Wired reports.

Reliance on Excel leads to errors in gene name lists, a new Genome Biology paper reports.