Gene Silencing/Gene Editing

In the study, company researchers explored treating corn rootworms with RNAi molecules that would interfere with the viability of their offspring.

Editas will earn an upfront payment of $25 million to launch three research programs to apply CRISPR/Cas9 and TALEN genome editing to Juno's immunotherapies.

The bodies will assemble an international committee to guide future research and have planned a summit this fall for experts to discuss the implications of the technology.

Commercial software packages with a suite of additional features offer an alternative to academic guide RNA design tools for CRISPR/Cas9 genome editing.

High-throughput, systematic screens found 25 protein domains essential to AML, including six that are already drug targets in clinical trials.

RNA sequence-specific mediators of RNA interference
Engineering and optimization of systems, methods, and compositions for sequence manipulation with functional domains
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
Method for expression of small RNA molecules within a cell
Analyzing messenger RNA and microRNA in the same reaction mixture
Methods and compositions for detection of small RNAs

In PNAS this week: spatiotemporal study of lncRNA expression, role of extrachromosomal, circular DNAs in yeast, and more.

A European team has launched a four-year study to develop a test to gauge cervical, ovarian, uterine, or aggressive breast cancer risk in women.

As interest in personalized medicine grows, government contractors are entering the field, the Washington Post reports.

In PLOS this week: Plasmodium knowlesi population genetics, oral microbiome of infants and children, and more.