Gene Editing & Gene Silencing | GenomeWeb

Gene Silencing/Gene Editing

After CRISPR/Cas9 makes a double-strand break in DNA and the cell repairs it, the same set of mutations crop up again and again based on the genomic sequence.

The company emerged from stealth mode this month and traces roots to both rocket maker SpaceX and the shuttered sequencing company Halcyon Molecular. 

The new method takes expressed mRNA and turns it into guide sequences for CRISPR/Cas9 knockout screening when bioinformatics-based design isn't an option.

The contract research organization said it has already used CRISPR/Cas9 editing in several customer projects and also plans to use it for internal R&D.

Scientists introduced an indel to a promoter region to mimic a benign, naturally-occurring mutation that activated fetal hemoglobin production.

Protein having nuclease activity, fusion protein and uses thereof
Construction of new variants of dextransucrase DSR-S by genetic engineering
Insect resistant cotton plants and methods for identifying same
Genomic plant sequences and uses thereof
Photocleavable oligonucleotide and uses thereof
Eukaryotic expression system and use thereof

In Science this week: role for epigenetic in neuronal excitability, and more.

The new Office of Research Integrity director is grappling with complaints from her staff, according to ScienceInsider.

Italian researchers link SNPs in the PDSS2 gene to coffee consumption in a new paper.

A gene-editing ban has been interpreted to include mitochondrial transfer, Technology Review reports.