Gene Silencing/Gene Editing

Reinstating the CRISPR patent interference with the Broad Institute would allow UC to argue that Jennifer Doudna and Emmanuelle Charpentier invented it first.

With Cas9 constructs fused to expression activators or repressors, researchers targeted chromatin-accessible sites to screen for regulatory element activity.

The technology, called Tunr, involves targeting translation elongation by introducing consecutive adenosine nucleotides into a gene coding sequence of interest.

Backed by VC firm Third Rock Ventures, Tango will develop new cancer therapies using sequencing and CRISPR/Cas9 genome editing in target discovery and development.  

The firm envisions applying its new PlexSet technology to the upper end of multiplex gene expression analysis as well as CRISPR validation applications.

RNA silencing in animals as an antiviral defense
Polynucleotides and polypeptides involved in post-transcriptional gene silencing
Cosmetic designs and products using intronic RNA
Methods and products for expressing proteins in cells
Compositions and methods for gene silencing
Installation of genomes or partial genomes into cells or cell-like systems

A fire at a Manchester hospital may have destroyed lab equipment and data, the Guardian reports.

Researchers generate a genetic database from skeletal remains from the 1845 Franklin Expedition to the Arctic, Live Science reports.

Researchers in China have begun another trial using CRISPR/Cas9 approaches in cancer patients, according to the Wall Street Journal.

In Science this week: human DNA found in sediments from archeological sites lacking bones, and more.