Gene Silencing/Gene Editing

The technology is for gene targeting using endocunleases and homologous recombination, and is the second licensing deal between the parties since April.

The scientists from UC Berkeley and UCSF said their method of introducing gene editing could lead to experiments in T cell function as well as immunotherapies.

CRISPR-EATING could enable scientists to create guide RNAs for CRISPR/Cas9 knock-out screens in organisms whose genomes are not yet sequenced.

By using both Fok1-dCas9 fusion proteins and truncated guide RNAs, the scientists were able to achieve a decrease in unwanted indel and point mutations.

The company said the library will be made freely available to academic and non-profit investigators through the DECIPHER Project.

Enhancer-containing gene trap vectors for random and targeted gene trapping
RNA sequence-specific mediators of RNA interference
Engineering and optimization of systems, methods, and compositions for sequence manipulation with functional domains
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
Method for expression of small RNA molecules within a cell
Analyzing messenger RNA and microRNA in the same reaction mixture

In Cell this week: map of human protein interactions, mutant phenotype variability in organisms of the same species from different genetic backgrounds, and more.

Critics call the Fred Hutchinson Cancer Research Center's Gary Gilliland's prediction of cancer cures within 10 years "out of touch with reality" and "irresponsible."

Ivan Oransky discusses the need for reproducibility research at The Conversation.

The San Diego Union-Tribune posts videos from Biocom's Speaker Series with Illumina's Jay Flatley, who discusses Roche's failed hostile takeover bid.