Gene Silencing/Gene Editing

The scientists from UC Berkeley and UCSF said their method of introducing gene editing could lead to experiments in T cell function as well as immunotherapies.

CRISPR-EATING could enable scientists to create guide RNAs for CRISPR/Cas9 knock-out screens in organisms whose genomes are not yet sequenced.

By using both Fok1-dCas9 fusion proteins and truncated guide RNAs, the scientists were able to achieve a decrease in unwanted indel and point mutations.

The company said the library will be made freely available to academic and non-profit investigators through the DECIPHER Project.

Researchers used RNA interference and automated trait analyses to systematically track phenotypes in Caenorhabditis elegans worms from two genetic backgrounds.

Enhancer-containing gene trap vectors for random and targeted gene trapping
RNA sequence-specific mediators of RNA interference
Engineering and optimization of systems, methods, and compositions for sequence manipulation with functional domains
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
Method for expression of small RNA molecules within a cell
Analyzing messenger RNA and microRNA in the same reaction mixture

In PNAS this week: human T cell editing with CRISPR, retrotransposons acting as insulators, and more.

The New York Times' George Johnson muses on cancer's roots in multicellularity.

The San Diego Union Tribune wonders whether Medicare is ready for personalized medicine.

Jun Wang, the chief executive of BGI, has stepped down.