gene signature

Focusing on drugs that appeared to reverse cancer-related gene expression signatures, researchers identified candidate compounds that thwarted cancer cell lines.

The PAM50 breast cancer classifier successfully split prostate cancer samples into luminal and basal subtypes with ties to patient outcomes and treatment response.

A team led by University of Toronto researchers developed the signature as a clinical assay that could predict treatment response.

This Week in Science

In Science this week: gene mutation signatures linked to tobacco smoke, and more.

Researchers have developed a gene expression signature of healthy aging that can identify people at risk of Alzheimer's disease.

The study results also offer hints to new pathways that might be targeted to overcome resistance to currently used DNA methyltransferase inhibitors.

Led by former LabCorp executives, the firm is aiming to develop evidence around genetic signatures and license the tech to labs and Dx developers.

Skyline will collaborate with Janssen to develop a test to identify patients at increased risk of side effects from a multiple myeloma drug.

Researchers have identified several gene expression signatures that predict a patient's sensitivity to adjuvant chemotherapy. A test based on the findings could help identify which patients will do well with current treatments, and which might benefit from entering a clinical trial.

The researchers found that treatment with lactate and ketones causes cancer cells to express gene profiles associated with “stemness.” They believe that these gene signatures could, in turn, predict poor clinical outcome in breast cancer patients.


The London School of Economics' Daniele Fanelli argues at the Proceedings of the National Academy of Sciences that the reproducibility crisis in science isn't as dire as some say.

A team of researchers in Portugal has examined the genomic basis for racing pigeons' athleticism and navigational skills, finding it's likely polygenic.

Wired reports that diagnostic firms continue to seek, post-Theranos, the ability to diagnose diseases from small amounts of blood.

In Science this week: analysis of DNA from ancient North Africans, and more.