gene mapping
Congenital Heart Defect Features of Down Syndrome Spelled Out with Transcriptomics, Mouse Models
Increased DYRK1A gene dosage led to altered expression of mitochondrial and cell proliferation genes in developing cardiac muscle cells, while DYRK1A inhibitors restored activity.
The Solna, Sweden-based company is currently expanding from offering in situ sequencing services to selling kits.
Microbial Genes Characterized in Human Gut, Oral Microbiomes
By analyzing metagenomic sequences found in thousands of human mouth and gut samples, researchers tracked down almost 45.7 million distinct microbial genes.
Type 1 Diabetes, Rheumatoid Arthritis Causal Variants Defined by Fine Mapping, Functional Analyses
Researchers used fine mapping and other approaches to prioritize proposed coding and non-coding causal variants at rheumatoid arthritis- and type 1 diabetes-linked loci.
Hay Fever Genetic Analysis Highlights Risk Loci Linked to Immune System
Data for hundreds of thousands of participants led to 20 new risk loci for allergic rhinitis, which were further examined by functional annotation and fine mapping.