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gene-environment interaction studies

Breast Cancer Outcomes Show Ties to Neighborhood Income in New Study

In estrogen receptor-positive breast cancer patients, lower income appeared to track with higher tumor expression-based recurrence scores, and shorter survival in the low-risk RS group.

Study Follows Geographic Impacts on Apparent Heritability of Complex Traits

Using data for siblings and unrelated individuals from the UK Biobank project, researchers teased out geographic contributions to risk scores for dozens of complex traits.

Thyroid Size, Function in Children Linked to Nutrition-Related DNA Methylation Mark

A trial in Gambia suggests PAX8 gene methylation in 2-year-olds corresponds to thyroid volume, hormone production, and physical features later in childhood.

Schizophrenia Associated With Blood DNA Methylation Signature

Investigators tracked down a methylation signature in blood that corresponded with features found in postmortem brain samples from schizophrenia cases.

Genetic Risk of Obesity Mitigated by Different Exercise Types, Taiwanese Study Finds

A gene-environment study involving more than 18,000 individuals suggests jogging and other forms of exercise may modify the genetic risk for obesity.

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The Scan

Suicidal Ideation-Linked Loci Identified Using Million Veteran Program Data

Researchers in PLOS Genetics identify risk variants within and across ancestry groups with a genome-wide association study involving veterans with or without a history of suicidal ideation.

Algorithm Teases Out Genetic Ancestry in Individuals at Biobank Scale

Researchers develop an algorithm known as Rye to tease apart ancestry fractions in admixed individuals at a biobank-scale, applying it to 488,221 UK Biobank participants in Nucleic Acids Research.

Multi-Ancestry Analysis Highlights Comparable Common Variants at Complex Trait-Linked Loci

Researchers in Nature Genetics examine common variants implicated in more than three dozen conditions, estimating genetic effect similarities across ancestry tracts in admixed individuals.

Sick Newborns Selected for WGS With Automated Pipeline

Researchers successfully prioritized infants with potential Mendelian conditions for whole-genome sequencing or rapid whole-genome sequencing, as they report in Genome Medicine.