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gene editing

The researchers used circularly permuted Cas9 variants to produce four cytosine and four adenine base editors with an expanded editing window.

Biohacker Gets Letter

Technology Review reports biohacker Josiah Zayner has been accused of practicing medicine without a license.

To solve the problem, the researchers developed new variants of the editors that still edit DNA efficiently but have significantly lower RNA editing activity.

As CRISPR technology continues to progress, some researchers are turning their focus to discovering or developing countermeasures and controls.

Researchers used the platform to identify small synthetic molecules that disrupt the editing activity of the SpCas9 nuclease.

Mismatch repair-deficient tumors with many insertion-deletion mutations and enhanced microsatellite instability responded better to anti-PD-1 immunotherapy.

Australia's ABC News looks into what's next after the country decides not to regulate some gene editing of plants and animals.

Australia will not be regulating gene editing of plants, animals, and human cell lines as long as no new genetic material is incorporated, reports Nature News.

The company launched last month with initial financing of $35 million and licenses to CRISPR and synthetic biology technology from the Broad and Harvard.

Researchers found that both CBEs and ABEs can cause transcriptome-wide RNA edits, which has implications for the research and therapeutic uses of base editors.

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The Guardian reports that visa costs could prevent scientists and others from coming to the UK.

The Trump Administration is reconsidering its plan to issue an executive order to require federally funded research to be freely available upon publication, Times Higher Education reports.

Nature News says some preprint repositories may close down due to a lack of funds to cover costs.

In Nature this week: framework for analyzing cancer mutational signatures, treatment resistance in small cell lung cancer followed by increased intratumoral heterogeneity, and more.