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gene editing

Researchers used a genome-scale CRISPRi platform to identify genetic interactions with an inhibitor for a mutant form of KRAS in models of lung and pancreatic cancer.

In Genome Research this week: repetitive element deletion linked to altered methylation and more in form of muscular dystrophy; human contamination in draft bacterial and archaeal genomes; and more.

The commission will develop a framework for scientists, clinicians, and regulatory authorities on the appropriate use of human germline genome editing. 

The researchers used circularly permuted Cas9 variants to produce four cytosine and four adenine base editors with an expanded editing window.

Biohacker Gets Letter

Technology Review reports biohacker Josiah Zayner has been accused of practicing medicine without a license.

To solve the problem, the researchers developed new variants of the editors that still edit DNA efficiently but have significantly lower RNA editing activity.

As CRISPR technology continues to progress, some researchers are turning their focus to discovering or developing countermeasures and controls.

Researchers used the platform to identify small synthetic molecules that disrupt the editing activity of the SpCas9 nuclease.

Mismatch repair-deficient tumors with many insertion-deletion mutations and enhanced microsatellite instability responded better to anti-PD-1 immunotherapy.

Australia's ABC News looks into what's next after the country decides not to regulate some gene editing of plants and animals.

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Gene editing could be an issue competitive sports need to address soon, four researchers from Arizona State University write at Slate.

A genetic alteration appears to increase heart failure risk among people of African descent, according to the Washington Post.

In his look back at the past decade, BuzzFeed News' Peter Aldhous writes that direct-to-consumer genetic testing has led to "Facebook for genes."

In Nature this week: genetic "clock" that can predict the lifespans of vertebrates, new assembler called wtdbg2, and more.