Researchers used the platform to identify small synthetic molecules that disrupt the editing activity of the SpCas9 nuclease.
Mismatch repair-deficient tumors with many insertion-deletion mutations and enhanced microsatellite instability responded better to anti-PD-1 immunotherapy.
Australia's ABC News looks into what's next after the country decides not to regulate some gene editing of plants and animals.
Australia will not be regulating gene editing of plants, animals, and human cell lines as long as no new genetic material is incorporated, reports Nature News.
The company launched last month with initial financing of $35 million and licenses to CRISPR and synthetic biology technology from the Broad and Harvard.
Researchers found that both CBEs and ABEs can cause transcriptome-wide RNA edits, which has implications for the research and therapeutic uses of base editors.
A Stanford University investigation finds that its researchers did not take part in He Jiankui's work to develop gene-edited infants.
NPR's Morning Edition reports that a number of CRISPR-based gene editing treatments are to be tested soon in humans in the US.
The team reported that engineering a hairpin secondary structure onto the spacer region of sgRNAs can increase specificity by several orders of magnitude.
Stanford University's Stephen Quake tells the New York Times that he encouraged CRISPR researcher He Jiankui to seek the proper ethical approvals.
The US Department of Justice has proposed a rule change to enable DNA to be collected from migrants, the Associated Press reports.
Bernard Fisher, a surgeon who changed how breast cancer is treated, has died at 101, the New York Times reports.
A Washington Post columnist writes that she is skeptical about DNA-based diets.
In PNAS this week: recurrent inactivation of DEPDC5 in gastrointestinal stromal tumors, taxonomic reliability of GenBank sequences, and more.