In Nature this week: catalog of changes associated with gene knockouts in yeast, simultaneous profiling of three-dimensional genome structure and DNA methylation in single cells, and more.
The team found that base editors that exhibit RNA off-target editing can also self-edit their own transcripts, leading to heterogeneity in their coding sequences.
The team tested the system in living mice with progeria, inserting a normal copy of the LMNA gene into the animals to diminish features of the disease.
In a point-counterpoint in the Boston Globe, researchers discuss the potential of gene editing to prevent Lyme disease, but also the pitfalls of doing so.
In PNAS this week: soil bacteria-derived small molecules affect centrosomal protein, microfluidics approach for capturing circulating tumor cells, and more.
