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gene editing

The nuclease, which comes from Bacillus hisashii, has gain-of-function mutations that facilitate robust editing in human cell lines and primary human T cells.

The protease-activated Cas9 enzymes could reduce off-target effects and could be used to sense pathogens and trigger an immune response.

The partners will work to find novel proteins, including DNA endonucleases, to develop new gene editing therapies for cystic fibrosis and other diseases.

An Associated Press poll finds that most US adults think it would be fine to use gene editing to prevent an incurable or fatal disease.

Watching CRISPR

The Los Angeles Times says CRISPR gene editing is a field to watch in the next year.

Ohio State University researchers found that a phosphorothioate-modified DNA-crRNA duplex completely blocked the function of Cas12a.

The firm is developing and beta-testing a line of guide RNA libraries to support CRISPR-based targeted capture and sequencing approaches.

This Week in Nature

In Nature this week: extension to uncultivated virus genome reporting standards, multiplex orthogonal CRISPR-based genome editing approach, and more.

Dual Challenges

The Washington Post reports on uncertainties facing gene-edited livestock endeavors.

The company, which had raised $55.5 million in February, said its investors have agreed to contribute an additional $30 million.

Pages

The American Prospect writes that the pilot program to test the DNA of migrants could lead to more family separations.

An international commission is to develop a report on how researchers, clinicians, and regulators should evaluate the clinical applications of human germline genome editing.

The US Department of Agriculture presents a new blueprint for animal genomic research.

In Genome Research this week: repetitive element deletion linked to altered methylation and more in form of muscular dystrophy; human contamination in draft bacterial and archaeal genomes; and more.