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gene editing

Interest Piqued

Stanford University's William Hurlbut says fertility clinics and others reached out to He Jiankui after his embryonic gene-editing announcement, the AP reports.

The protocol involves using CRISPR-Cas9 gene editing to knock out the NRF2 gene in KRAS-positive NSCLC patients who have become resistant to chemotherapy.

The FLASH method, which depletes unwanted DNA from samples, allows labs to perform deep metagenomic sequencing on smaller, less expensive instruments.

Researchers used a genome-scale CRISPRi platform to identify genetic interactions with an inhibitor for a mutant form of KRAS in models of lung and pancreatic cancer.

In Genome Research this week: repetitive element deletion linked to altered methylation and more in form of muscular dystrophy; human contamination in draft bacterial and archaeal genomes; and more.

The commission will develop a framework for scientists, clinicians, and regulatory authorities on the appropriate use of human germline genome editing. 

The researchers used circularly permuted Cas9 variants to produce four cytosine and four adenine base editors with an expanded editing window.

Biohacker Gets Letter

Technology Review reports biohacker Josiah Zayner has been accused of practicing medicine without a license.

To solve the problem, the researchers developed new variants of the editors that still edit DNA efficiently but have significantly lower RNA editing activity.

As CRISPR technology continues to progress, some researchers are turning their focus to discovering or developing countermeasures and controls.

Pages

The US Department of Justice has proposed a rule change to enable DNA to be collected from migrants, the Associated Press reports.

Bernard Fisher, a surgeon who changed how breast cancer is treated, has died at 101, the New York Times reports.

Washington Post columnist writes that she is skeptical about DNA-based diets.

In PNAS this week: recurrent inactivation of DEPDC5 in gastrointestinal stromal tumors, taxonomic reliability of GenBank sequences, and more.