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The percentage of perfectly modified alleles using the new base editor is more than 6,000-fold for disease correction compared with the current BE4max editor.
Unlike previously described cytidine deaminases, this toxin catalyzes the deamination of cytidines within double-stranded DNA, the researchers said.
Using computational modeling, researchers developed tools that they said will facilitate modeling and correction of genetic diseases by base editing.
NPR reports that the first person in the US to undergo a CRISPR-based treatment for sickle-cell disease continues to do well nearly a year after treatment.
Christiana Care researchers have identified a unique protospacer adjacent motif site that allows them to knock out the NRF2 gene in tumor cells while leaving normal cells alone.
The technique could be used to study DNA repair at high resolution in space, time, and genomic coordinates, the researchers said.
The firms are targeting a compatible offering for single-cell gene expression screens following CRISPR-based editing, with applications in drug discovery.
Three teams have developed base editors that combine the abilities of adenine and cytosine base editors, allowing for concurrent A-to-G and C-to-T edits.
The platform can detect a single virus in more than 1,000 samples at a time or more than 160 viruses, including SARS-CoV-2, in a small number of samples.
The Cambridge, UK-based firm saw double-digit growth in its screening business and declines in its bioproduction and diagnostics businesses.
NPR reports that researchers have developed chimeric embryos as part of work toward growing human organs in animals for organ transplants.
According to the Washington Post, the Biden Administration is set to make changes to federal restrictions on fetal tissue research.
In Science this week: approach to isolated trace DNA from archaic humans from sediments, and more.
Texas Monthly looks into the DNA Zoo being collected by Baylor College of Medicine researchers.