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gene editing

Genes influencing NOTCH pathway activity were linked to head and neck squamous cell carcinoma with a mouse screen centered on genes with long tail mutations in human cases.

The company is in talks with potential partners in the US and China to validate the assay on clinical samples and deploy it at a large scale.

The company recently inked deals with Mammoth Biosciences and Rutgers University to license a protein discovery platform and gene editing technology.

The EPO rejected arguments that were filed in opposition to the patent, which covers the use of CRISPR-Cas9 in cellular and non-cellular settings.

The company said revenue growth during the year was driven by performance in its research reagents and screening business units.

The company, which recently signed a licensing agreement with Horizon Discovery, just raised $45 million in a Series B financing round.

The European Patent Office appeals board upheld the decision made by the EPO after its initial review in 2018.

And Prize

Jennifer Doudna and Emmanuelle Charpentier are being awarded Israel's Wolf Prize in medicine for their CRISPR work, the Associated Press reports.

In PNAS this week: population genomics study on indigenous individuals in Brazil, programmable genome-editing approach, and more.

Horizon also said it will provide access to the technology to business partners for the development of more effective multi-gene knockout cell therapy programs.

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The Hastings Center's Erik Parens argues in a Scientific American opinion piece that the current pandemic underscores the need to reconsider the hope placed in genomic medicine. 

The Los Angeles Times writes that Operation Warp Speed has an ambitious timeline for developing a COVID-19 vaccine.

The Sydney Morning Herald reports that Australia is launching its trial of preconception carrier testing Tuesday.

In PNAS this week: autosomal genes commonly affected by loss-of-function variants, variants implicated in testis development disorders, and more.