functional genomics
Raynaud's Syndrome Genetics, Biology Uncovered in GWAS, Functional Study
A large genome-wide association study and meta-analysis identified eight Raynaud's syndrome-related loci, pointing to multiple proposed disease mechanisms.
UK Research and Innovation Launches £28.5M Human Functional Genomics Initiative
The multi-institute research program is focused on understanding the role of genomic variation in human physiology and disease.
Type 2 Diabetes Development Linked to GWAS-Informed Regulatory Modules
Researchers used transcriptomic and functional analyses to find regulatory modules for early-stage type 2 diabetes, focusing in on a module containing the beta cell-related gene RFX6.
Screening Study IDs Functions for Conserved Proteins in 'Unknome' Collection
Investigators used RNAi screening and CRISPR editing validation testing in fruit flies to untangle functional contributions for conserved proteins with unknown functions.
Type 2 Diabetes, Osteoarthritis Comorbidity Traced to Obesity-Related Processes
Researchers turned to genotyping, multiomics, and functional studies to untangle the processes contributing to type 2 diabetes and hip/knee osteoarthritis.