functional genomics Engine Biosciences Using CRISPR, Machine Learning to Build Drug Candidate Pipeline Premium Fresh off a $43 million fundraising round, the drug discovery-focused bioinformatics firm is validating novel drug targets and compounds with an eye toward 2023 clinical trials. Genomenon, Nostos Genomics to Integrate Technologies to Improve Rare Disease Dx Genomenon will embed its Mastermind genomic search engine into the AI-driven Nostos AIon variant interpretation platform to power clinical decision support. At ACMG, Mechanism for Common Breast Cancer Locus Proposed From Functional Analysis With regulatory and functional data, investigators saw a possible tumor suppressor role for a gene flagged by common variants in a breast cancer GWAS. Giraffe Genome Assembly, Functional Analyses Highlight Variants Linked to Height Adaptations The findings could additionally inform future studies of cardiovascular disease and hypertension treatments for people. Genomics Plc Looks to Grow 'Genomic Prevention' With Polygenic Risk Scores Premium In two recent papers, the UK startup demonstrated the integration of polygenic risk scoring into primary care screening and workflows. Feb 19, 2021 BRCA2 Variants of Unknown Significance Reclassified Through Functional Data Additions Feb 11, 2021 Neanderthal Gene Variant Alters Neurodevelopment in Human Brain Organoids Nov 12, 2020 Masking Variants Can Protect Genetic Privacy While Enabling Data Sharing Oct 5, 2020 Berkeley Lights Helps Researchers Connect Genomic, Functional Characteristics of Cells Premium Sep 8, 2020 Polygenic Risk Scores Provide Insights Into Drug-Related Liver Injury May 21, 2020 ALK Gene Linked to Natural Thinness in Genetic, Functional Studies May 13, 2020 The DNA Company Rebrands as My Next Health Following Acquisition Jan 23, 2020 Autism Sequencing Study Uncovers New Disease-Associated Genes, Functional Clues Jan 21, 2020 Urinary Metabolite GWAS Leads to Risk Variants, Potential Markers of Kidney Disease Jan 9, 2020 Heart Failure GWAS Leads to Risk Loci, Causal Clues Jul 19, 2019 New Type 2 Diabetes Locus Identified in GWAS of African Populations Jun 13, 2019 Fetal Genetic Variants Implicated in Spontaneous Preterm Birth Risk Apr 10, 2019 Genomic Study Uncovers Human Bloodstream Infection Adaptations in Historical Hospital Samples Mar 28, 2019 Schizophrenia Genes Prioritized in Zebrafish Mutant Study Mar 5, 2019 Carpal Tunnel GWAS Highlights Growth-Related Loci, Genetic Ties to Height Oct 11, 2018 Stanford Researchers Use CRISPR to Manipulate Genome Organization in 3D Sep 18, 2018 Type 1 Diabetes, Rheumatoid Arthritis Causal Variants Defined by Fine Mapping, Functional Analyses Jul 17, 2018 Hay Fever Genetic Analysis Highlights Risk Loci Linked to Immune System Jul 16, 2018 Harvard Team Combines SNP-Seq, FREP to Identify Non-Coding Functional SNPs May 24, 2018 Functional Assays Improve Classification of Potential Cystic Fibrosis Risk Variants Load More Breaking News Sequencing Study Uncovers MERS-Related Coronavirus in Swiss Bats Angstrom Bio Raises $3M in Private Financing Eagle Biosciences, Genetic Analysis Ink Distribution Agreement for Gut Microbiota Test Centogene Q1 Revenues Grow More Than Fivefold Driven by COVID-19 Testing Epizyme Partnering With Quest Diagnostics for Lymphoma Mutation Testing Enzo Biochem, CLX Health Partner to Support COVID-19 Testing for International Travel The Scan CDC Calls Delta "Variant of Concern" CNN reports the US Centers for Disease Control and Prevention now considers the Delta variant of SARS-CoV-2 to be a "variant of concern." From FDA to Venture Capital Former FDA Commissioner Stephen Hahn is taking a position at a venture capital firm, leading some ethicists to raise eyebrows, according to the Washington Post. Consent Questions Nature News writes that there are questions whether informed consent was obtained for some submissions to a database of Y-chromosome profiles. Cell Studies on Multimodal Single-Cell Analysis, Coronaviruses in Bats, Urban Microbiomes In Cell this week: approach to analyze multimodal single-cell genomic data, analysis of bat coronaviruses, and more.