functional genomics Osteoarthritis GWAS Leads to Key Genes, Treatment Targets With a genome-wide association study and functional follow-up analyses, investigators saw 100 osteoarthritis-related loci including variants in potentially targetable genes and pathways. Rare Variants in G Protein-Coupled Receptor Gene May Provide Protection From Obesity The Regeneron Pharmaceuticals-led team also said that inhibiting the gene could represent a potential therapeutic strategy for obesity. New ALS Risk Gene Suggests Role for Apoptosis Rare variants in the TP73 gene affect protein function, increase apoptosis, and lead to the impaired development of motor neurons, according to a new study. Engine Biosciences Using CRISPR, Machine Learning to Build Drug Candidate Pipeline Premium Fresh off a $43 million fundraising round, the drug discovery-focused bioinformatics firm is validating novel drug targets and compounds with an eye toward 2023 clinical trials. Genomenon, Nostos Genomics to Integrate Technologies to Improve Rare Disease Dx Genomenon will embed its Mastermind genomic search engine into the AI-driven Nostos AIon variant interpretation platform to power clinical decision support. Apr 15, 2021 At ACMG, Mechanism for Common Breast Cancer Locus Proposed From Functional Analysis Mar 17, 2021 Giraffe Genome Assembly, Functional Analyses Highlight Variants Linked to Height Adaptations Mar 17, 2021 Genomics Plc Looks to Grow 'Genomic Prevention' With Polygenic Risk Scores Premium Feb 19, 2021 BRCA2 Variants of Unknown Significance Reclassified Through Functional Data Additions Feb 11, 2021 Neanderthal Gene Variant Alters Neurodevelopment in Human Brain Organoids Nov 12, 2020 Masking Variants Can Protect Genetic Privacy While Enabling Data Sharing Oct 5, 2020 Berkeley Lights Helps Researchers Connect Genomic, Functional Characteristics of Cells Premium Sep 8, 2020 Polygenic Risk Scores Provide Insights Into Drug-Related Liver Injury May 21, 2020 ALK Gene Linked to Natural Thinness in Genetic, Functional Studies May 13, 2020 The DNA Company Rebrands as My Next Health Following Acquisition Jan 23, 2020 Autism Sequencing Study Uncovers New Disease-Associated Genes, Functional Clues Jan 21, 2020 Urinary Metabolite GWAS Leads to Risk Variants, Potential Markers of Kidney Disease Jan 9, 2020 Heart Failure GWAS Leads to Risk Loci, Causal Clues Jul 19, 2019 New Type 2 Diabetes Locus Identified in GWAS of African Populations Jun 13, 2019 Fetal Genetic Variants Implicated in Spontaneous Preterm Birth Risk Apr 10, 2019 Genomic Study Uncovers Human Bloodstream Infection Adaptations in Historical Hospital Samples Mar 28, 2019 Schizophrenia Genes Prioritized in Zebrafish Mutant Study Mar 5, 2019 Carpal Tunnel GWAS Highlights Growth-Related Loci, Genetic Ties to Height Oct 11, 2018 Stanford Researchers Use CRISPR to Manipulate Genome Organization in 3D Sep 18, 2018 Type 1 Diabetes, Rheumatoid Arthritis Causal Variants Defined by Fine Mapping, Functional Analyses Load More Breaking News Ancient DNA Analysis Highlights Three Ancestral Populations in Japan FDA Warns of Potential False Positives With Abbott SARS-CoV-2 Molecular Tests New Products Posted to GenomeWeb: Oxford Nanopore, Beckman Coulter, Thermo Fisher Scientific, More People in the News: New Appointments at Sema4, NHGRI, Dante Labs, Ancestry, More Thermo Fisher Scientific Expects 12 Percent Revenue Growth in 2022 In Brief This Week: Myriad Genetics, Danaher, Co-Diagnostics, and More The Scan For Those Thick Tiger Stripes Tigers in India with thick stripes harbor a genetic change, as Gizmodo reports. High GABA Tomatoes The Japan News reports that genome-edited tomatoes with higher GABA levels are now for sale in Japan. Approach for Inclusivity and Diversity A National Human Genome Research Institute team calls for the field to "adopt diversity as an ethos." Science Papers on Tumors Immune System Evasion; Drivers of Genomic Instability, Inflammation In Science this week: study of how tumors evade the adaptive immune system, and more.