FISH
Medulloblastoma Long-Read Sequences Reveal Complex Rearrangements, Methylation Changes
With Oxford Nanopore sequencing, researchers found DNA methylation clues and complex rearrangement patterns that were subsequently assessed in a broader cancer set.
Oxford Gene Technology Obtains CE-IVDR Certificates for FISH Products
According to the Oxford, UK-based company, the probes are important for patient management while treating hematological cancers and prenatal conditions.
End-Stage Ovarian Cancer Marked by Rampant Treatment Resistance, Multiple Clones
By profiling multiple tumors per patient, researchers found pronounced polyclonal disease and diverse resistance mechanisms in end-stage high-grade serous ovarian carcinoma.
Extrachromosomal DNA Appears to Boost Cancer Adaptability, Impact Drug Response
Researchers demonstrated that random inheritance of extrachromosomal DNAs can boost cancer development, while helping a subset of tumor cells adapt to evade treatment.
Repeat Biomarker Testing Informs Next Steps for Treatment-Resistant EGFR-Mutant NSCLC Patients
Premium
Studies at ESMO showed the importance of repeat biomarker testing to guide treatment after resistance to AstraZeneca's Tagrisso, but tissue-based testing remains a hindrance.