drug screening

Researchers screened cancer cell lines to detect mutations and drug combinations that might sensitize tumors to drugs that impair anti-apoptosis proteins.

Agilent and CRO PureHoney will develop new applications for the RapidFire 365 system, including workflows for pharmaceutical research, forensics, and metabolomics.

The firm's platform combines proprietary algorithms and software with its integrated genome-phenome database to uncover relationships between genetic variation and human health outcomes.

Horizon CombinatoRx will be paid $750,000 for the five-month project. 

NEW YORK (GenomeWeb) – The National Institutes of Health has awarded $17 million to fund 11 research groups seeking to develop 3-D human tissue chips that can be used to predict drug safety and effectiveness, NIH said today.

NEW YORK (GenomeWeb News) – Horizon Discovery announced today a research service agreement to deploy its X-MAN isogenic cell lines in support of Blueprint Medicine's "New Targets" discovery platform.

NEW YORK (GenomeWeb News) – Certara said this week that it is working with the Critical Path Institute, C-Path, to create a physiologically-based pharmacokinetic model of the human lung using Certara's Simcyp Population-based simulator software that will be used to test new tuberculosis drugs.

NEW YORK (GenomeWeb News) – Bayer Healthcare and the Broad Institute today announced a strategic alliance to jointly discover and develop therapeutic agents that target cancer genome alterations.

NEW YORK (GenomeWeb News) – The international non-profit Drugs for Neglected Diseases Initiative (DNDi) and the Institut Pasteur Korea (IP-K) will collaborate to screen for and examine molecules that may be used as new treatments for certain "neglected" diseases, IP-K said today.

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A fire at a Manchester hospital may have destroyed lab equipment and data, the Guardian reports.

Researchers generate a genetic database from skeletal remains from the 1845 Franklin Expedition to the Arctic, Live Science reports.

Researchers in China have begun another trial using CRISPR/Cas9 approaches in cancer patients, according to the Wall Street Journal.

In Science this week: human DNA found in sediments from archeological sites lacking bones, and more.