drug metabolism

Results from a randomized clinical trial known as GIFT suggest that genotype-guided warfarin dosing is linked to fewer adverse events than clinical dosing.

Data from several large cohorts suggests that a variant in LILRB5 may produce a propensity for muscle pain or myalgia, upping the risk of statin intolerance.

The effort is already bearing fruit, as the team has been able to validate several variants known to be connected with adverse drug reactions.

This Week in Cell

In Cell this week: host-microbe interactions and cancer drug response; links between transcription rate, mRNA translation, and methylation; and more.

A study led by researchers from Brigham and Women's Hospital on the effect of CYP2C19 testing on physicians' prescribing patterns has found that when doctors received patient test results for genetic markers associated with clopidogrel response through a pharmacy-benefit manager-

Genewiz, a contract research organization specializing in sequencing and other genomic services, has announced that it is branching out into the clinical sequencing and personalized medicine space with two sequencing panels — a 25-gene general pharmacogenomic panel and a 35-gene

NEW YORK (GenomeWeb News) – Luminex said after the close of the market on Monday that its xTAG CYP2C19 kit has been cleared for marketing by the US Food and Drug Administration and has received the CE Mark in Europe.

This article has been updated to clarify that the test has not been cleared for use in a point-of-care setting.

NEW YORK (GenomeWeb News) – Luminex announced after the close of the market Monday that the US Food and Drug Administration has cleared for marketing a new version of its xTAG CYP2D6 kit.

With a $150,000 grant from the National Human Genome Research Institute, startup Twistnostics is hoping to demonstrate the potential of its single-molecule array technology to support rapid multiplex molecular diagnostics.

Pages

The US Food and Drug Administration has approved Kite Pharmaceuticals' CAR T-cell therapy for large B-cell lymphomas, the New York Times reports.

Kaiser Health News reports that gene therapies could cost more than a million dollars.

Worcester Polytechnic Institute researchers have received a grant to combine biology and computer science for high school students.

In Nature this week: variants associated with obsessive-compulsive disorder, review of key CRISPR enzymes, and more.