de novo sequencing | GenomeWeb

de novo sequencing

The researchers sequenced bacteria samples sourced from all over the world to reconstruct a phylogenetic tree and learn how it evolved to have multidrug resistance. 

At the conference, the Broad Institute's David Jaffe presented a strategy for sequencing reference genomes from many different horses for an estimated price tag of around $25,000 apiece.

By doing exome sequencing on individuals from 14 families affected by sporadic schizophrenia, researchers have identified de novo mutations specifically found in individuals with the psychiatric condition.

The researchers sequenced the genome to five-fold coverage on Roche's 454 GS FLX and covered around 95 percent of known wheat genes. Over the next year, the researchers will sequence four additional varieties on Life Technologies' SOLiD.

The study is one of the first in which researchers sequenced and de novo assembled a large mammalian genome using only short-read technology

The institute said that it has so far used the Illumina platform for the "rapid, accurate, and cost-effective completion of several large genome projects … including the giant panda genome."

Startup companies are taking on personalized medicine, CNET reports.

Bruce Booth writes at Life Sci VC that biotech clusters like Boston and San Francisco are getting even more consolidated.

The Verge speaks with Mark and Scott Kelly, who are the subjects of NASA's Twin Study.

In Genome Biology this week: genes linked to Hirschsprung disease, structural variant patterns in autism, and more.