de novo assembly

The effort aims to sequence at least 150 animals, plants, and microbes selected for their potential benefits to Canada in the next three years.

Solenodon

Using an atypical assembly strategy, researchers tackled the genome of Solenodon paradoxus, an endangered venomous, shrew-like animal from Hispaniola.

An Australian team used Pacific Biosciences long reads, 10X Genomics linked reads, and Bionano Genomics mapping to assemble a desert dingo genome de novo.

The firms will combine PacBio's single-molecule sequence data and de novo assembly with Bluebee's cloud-based genomics analysis platform.

Under an NIH grant, the firm plans to develop its Chicago method to analyze fecal metagenomic samples without relying on first culturing the bacteria.

Scientists reported this week for the first time a Danish reference genome based on the de novo assembly of 150 genomes from 50 family trios.

The Brown University spinout plans to market its instrument, Nabsys HD-Mapping, for genome mapping, de novo assembly, and structural variant detection. 

In Genome Research this week: repetitive satellite DNA in the fruit fly, transcriptome map assembly pipeline, and more.

Increasingly, researchers are combining sequencing, mapping, and scaffolding technologies to generate more contiguous and accurate reference genomes. 

An international coalition sequenced the full genome of an Australian pitcher plant and compared it to both carnivorous and non-carnivorous plants.

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.