CRISPR

The team reported that its coordinated formation of paired single-stranded DNA breaks yielded higher frequencies of accurately edited cells.

The team used CRISPR to inactivate a gene in colon organoids, and found that a specific DNA repair defect underlies a mutational signature in some cancers.

The investment bank began coverage with an Outperform rating, noting that Horizon's recent acquisition of Dharmacon is highly complementary and synergistic.

The researchers used this approach to show how non-coding variation associated with human immune dysfunction alters context-specific gene programs. 

Doudna will get $2.1 million to set up the Center for Genome Editing and Recording, and Zhang will get $1.1 million to develop tools for RNA interrogation.