CRISPR Cardiac-Related Consequences of Alcohol Flushing Genetic Variant Reduced by Drug With endothelial cells derived from induced pluripotent stem cells, researchers tracked functional changes and potential treatment targets in alcohol flushing variant carriers. CRISPR QC Raises $1.6M in Seed Funding The San Diego-based startup said its CRISPR analytics platform can directly measure CRISPR activity to "optimize and de-risk gene editing outcomes." Glioblastoma With Wild-Type TP53 Linked to Potentially Targetable Epigenetic Alteration With the help of a CRISPR-based screen, researchers linked enhanced activity by the chromatin regulatory gene BRD8 to altered p53 function in cells containing wild-type TP53. Computational Tool Tracks Genetic Variation Effects of Off-Target Gene Editing Researchers came up with a strategy for predicting off-target edits related to genetic variation, using it to assess off-target variant effects on a potentially therapeutic guide RNA. Cleft Lip-Palate CNV Analysis Uncovers New Clefting Genes Researchers profiled copy number variants in more than 1,100 individuals, identifying duplications or deletions in known disease genes and in new clefting gene candidates. Dec 8, 2022 ERS Genomics Licenses CRISPR-Cas9 Patents to Crown Bioscience Dec 1, 2022 ERS Genomics Licenses CRISPR-Cas9 IP to Cosmo Bio Nov 29, 2022 Sherlock Biosciences Awarded $2M by Gates Foundation for Instrument-Free Diagnostics Nov 28, 2022 Programmable CRISPR-Based Tool 'Pastes' in New Genes While Avoiding Double-Strand Breaks Nov 10, 2022 Cancer Patients in Early Trial Receive Personalized, CRISPR-Edited T-Cell Therapy Nov 1, 2022 UPDATE: Sherlock Biosciences, Tolo Biotech Reach Another CRISPR Licensing Agreement for Dx Oct 26, 2022 Sherlock Biosciences Adds Ambient Amplification to Infectious Disease Diagnostic Toolkit Premium Oct 20, 2022 CRISPR Screens Identify Potential Host Targets to Reverse HIV-1 Latency Oct 19, 2022 MorPhiC Initiative to Test Strategies to Characterize Function of Every Human Gene at Scale Premium Oct 19, 2022 Telesis Bio, Cellibre Partner to Validate CRISPR Guide RNA Synthesis Instrument Oct 17, 2022 Sherlock Biosciences Licenses Ambient Temperature Amplification Tech From Wyss Institute Oct 6, 2022 CRISPR-SpRYgests Enable Precise Cleavage of DNA Bases In Vitro Sep 27, 2022 Colossal Biosciences Informatics Spinoff Form Bio Launches With $30M in Series A Financing Premium Sep 23, 2022 Researchers Demonstrate Multiplex Codon Editing in the Human Genome Premium Sep 20, 2022 GenScript, Avectas Partner on Cell Therapy Manufacturing Sep 19, 2022 Extrachromosomal DNA Appears to Boost Cancer Adaptability, Impact Drug Response Sep 8, 2022 Boost to Modern Human Brain Linked to Single Amino Acid Substitution Sep 8, 2022 New CRISPR-Based DNA Recorder Tracks Order of Transcriptional Events in Bacterial Cells Premium Sep 8, 2022 Sigma-Aldrich, GenOway Modify CRISPR Strategic Alliance Aug 31, 2022 Mammoth Biosciences Develops SNP-Detecting CRISPR System for SARS-CoV-2 Variant Surveillance Premium Load More Breaking News New Products Posted to GenomeWeb: Qiagen, Thermo Fisher, Bionano Genomics, BillionToOne, More People in the News at Illumina Ventures, Element Biosciences, Epigenomics, Exagen, More Genomic Approaches Boost Rare Disease Diagnoses in Middle Eastern Patient Population GeneDx to Raise $150M in Public and Direct Stock Offerings In Brief This Week: T2 Biosystems, Novacyt, OpGen, Dante Genomics, Nautilus Biotechnology, More The Scan Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups. Genome-Wide Analysis Sheds Light on Genetics of ADHD A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder. MicroRNA Cotargeting Linked to Lupus A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus. Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.