Researchers found that both CBEs and ABEs can cause transcriptome-wide RNA edits, which has implications for the research and therapeutic uses of base editors.
The team reported that engineering a hairpin secondary structure onto the spacer region of sgRNAs can increase specificity by several orders of magnitude.
In PLOS this week: 'reverse genome-wide association study' method; genetic links between Familial Mediterranean Fever and ankylosing spondylitis; and more.
St. Jude Children's Research Hospital scientists have treated infants with X-linked severe combined immunodeficiency using gene therapy in an early phase study.
In Nature this week: a genomic analysis of the snailfish Pseudoliparis swirei, ancient DNA analysis gives insight into the introduction of farming to England, and more.
