CRISPR

The researchers were able to measure the fitness effects of thousands of natural genetic variants in yeast at single-base resolution.

In the Skin

Researchers have transplanted edited cells into mice that appear to combat cocaine addiction, New Scientist reports.

Under the terms of the agreements, Thermo Fisher obtains global non-exclusive rights to products, tools, and research services involving the technologies.

The firm said it saw a robust contribution in the first half of the year from its Dharmacon business and noted that it increased its reach into the US market.

This Week in Nature

In Nature this week: saturation genome editing gives insight into BRCA1 variant functions, system to identify CRISPR off-target effects, and more.

The international team then used the approach to show that appropriate guide RNA design can reduce off-target effects of editing in mouse livers.

The researchers said their findings could help classify BRCA1 variants, particularly one whose impact on cancer risk is currently not clear.

A federal appeals court in the US has upheld a judgment that gave the Broad Institute key CRISPR patents.

A new study shows that DNA targets bound by nucleosomes are cleaved less efficiently than targets lacking nucleosomes, which could inform target selection.

The court upheld a judgement of no interference-in-fact from the Patent Trial and Appeal Board, leaving the Broad in control of key CRISPR IP.

Pages

The New York Times and ProPublica look into the close relationship between a startup and Memorial Sloan Kettering Cancer Center.

Yahoo News reports millions of dollars are being transferred from NIH, CDC, and other programs to pay for the housing of detained undocumented immigrant children.

Researchers gave a handful of octopuses MDMA to find that they too act more social on the drug, Gizmodo reports.

In Science this week: in vitro generation of human reproductive cells, and more.