CRISPR
Cardiac-Related Consequences of Alcohol Flushing Genetic Variant Reduced by Drug
With endothelial cells derived from induced pluripotent stem cells, researchers tracked functional changes and potential treatment targets in alcohol flushing variant carriers.
CRISPR QC Raises $1.6M in Seed Funding
The San Diego-based startup said its CRISPR analytics platform can directly measure CRISPR activity to "optimize and de-risk gene editing outcomes."
Glioblastoma With Wild-Type TP53 Linked to Potentially Targetable Epigenetic Alteration
With the help of a CRISPR-based screen, researchers linked enhanced activity by the chromatin regulatory gene BRD8 to altered p53 function in cells containing wild-type TP53.
Computational Tool Tracks Genetic Variation Effects of Off-Target Gene Editing
Researchers came up with a strategy for predicting off-target edits related to genetic variation, using it to assess off-target variant effects on a potentially therapeutic guide RNA.
Cleft Lip-Palate CNV Analysis Uncovers New Clefting Genes
Researchers profiled copy number variants in more than 1,100 individuals, identifying duplications or deletions in known disease genes and in new clefting gene candidates.