CRISPR
BRCA2 Variants Classified in Saturation Genome Editing Studies
Research teams relied on CRISPR-Cas9-based editing and sequencing to perform high-throughput function evaluations of loss-of-function variants in exons 15 to 26 of BRCA2.
Metastatic Cancer Development Dialed Down by Extracellular Vesicle DNA
DNA-containing extracellular vesicles appeared to help clear damaged DNA from tumor cells while providing antitumor information to immune cells.
'Evo' AI Tool Trained to Model, Design Prokaryotic Genomes
After training a model called Evo with prokaryote genomes and phage sequences, researchers demonstrated its ability to predict sequence effects and generate new sequences.
Human Tumor Atlas Collection Reveals 3D Features of Cancer Tissue, Microenvironment
A dozen papers put out by investigators in the Human Tumor Atlas Network are revealing complex features and interactions found in tumors and their surroundings over time.
Cancer Cell Line Study Reveals Drug Resistance, Sensitivity Mechanisms
Researchers used systematic gene editing and transcriptomics to find treatment response-related variants in drug-treated cancer cell lines, defining four functional variant classes.