NEW YORK (GenomeWeb News) – Stretches of DNA with especially low levels of methylation are prone to genomic instability, providing fodder for structural changes that can contribute to evolutionary change and human disease, according to a study appearing online last night in PLoS Genetics
By Andrea Anderson
NEW YORK (GenomeWeb News) – Aging is associated with an uptick in somatic, structural changes in the human genome, a new study online in the American Journal of Human Genetics suggests.
By a GenomeWeb staff reporter
NEW YORK (GenomeWeb News) – Affymetrix today announced a collaboration with the Broad Institute to chart the genomic changes in more than 20 cancer types as part of the Broad's work on The Cancer Genome Atlas.
Using a combination of whole-exome sequencing and expression, methylation, and copy number analyses, members of The Cancer Genome Atlas have characterized hundreds of high-grade serous ovarian cancer samples.
By identifying inherited, rare copy number variants specific to families affected by autism spectrum disorders, researchers have identified several biological pathways that may contribute to the disease.