copy number analysis
Spatial Copy Number Variant Maps Shed Light on Clonal Cancer Development
Spatially resolved copy number profiles in malignant and benign tissues across organ types led to the detection of ancestral clones at seemingly cancer-free sites.
UK Biobank Copy Number-Based GWAS Discovers New Associations With Human Traits
Using new CNV analysis tools called CNest, researchers found almost 900 ties between CNVs and phenotypes in exome sequencing data from the UK Biobank.
NCCN Publishes First Guidelines for Pediatric Brain Cancer, Recommends Broad NGS Profiling
The guidelines recognize the importance of molecular profiling in diagnosing, treating, and identifying clinical trial opportunities for children with high-grade gliomas.
Scientists from the University of Florence in Italy applied nanopore sequencing to effectively detect known copy number variants in a small cohort of patients.
Pan-Cancer Analyses Reveal Copy Number Signatures, Chromosomal Instability Patterns
Investigators identified up to 21 copy number signatures in cross-cancer analyses, including potential disease response markers and signatures linked to chromosomal instability features.