comparative genomics
Mycobacterium Tuberculosis Genomes Provide Resistance, Outcome Clues
With genome sequences for 1,960 clinical isolates, researchers searched for small to large M. tuberculosis genetic variants influencing drug resistance and patient outcomes.
Malaria History, Colonization-Related Spread Revealed in Ancient DNA Sequencing Study
After flagging Plasmodium isolates in ancient DNA metagenomic datasets, researchers used capture-based sequencing to retrace international spread of malaria-causing parasites.
Study Reveals History, Distribution of Plant-Degrading Microbes in the Human Gut
Researchers unearthed cellulose-degrading microbes that have decreased in the human gut with industrialization, but that may offer nutritional benefits.
Measles Virus Mutations Found to Drive Rare Lethal Brain Infection
Researchers turned to deep genome sequencing on brain autopsy samples to understand measles virus features involved in a rare, usually deadly form of encephalitis.
Comparison of 239 Primate Genomes Reveals Conserved Regulatory Sequences
By aligning and comparing whole-genome sequences for 239 species, researchers identified regulatory elements that have become constrained specifically in primates.