comparative genomics
Comparison of 239 Primate Genomes Reveals Conserved Regulatory Sequences
By aligning and comparing whole-genome sequences for 239 species, researchers identified regulatory elements that have become constrained specifically in primates.
Mpox Transmitted Between Humans for Several Years, Study Finds
By analyzing mpox virus mutations introduced by APOBEC deaminase enzymes in human hosts, researchers traced steady transmission between humans back to late 2015 or early 2016.
Plasmid Transfer Let Cholera Pathogen in Yemen Become Multidrug Resistant, Study Suggests
By analyzing genome sequences for 260 Vibrio cholerae isolates from an outbreak in Yemen, researchers identified a persistent drug resistance plasmid in the cholera pathogen.
Human-Specific Features Found With CRISPR Screening on Stem Cells
With loss-of-function screens on human, chimp, and orangutan stem cells, researchers narrowed in on species-specific genetic dependencies involving dozens of genes.
Pan-Cancer Genome Analyses Reveal Metastatic, Immune Escape Patterns
With whole-genome sequencing on more than 7,100 primary or metastatic tumors, researchers untangled disease progression, treatment resistance, and immune escape features.