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Cold-PCR

Researchers affiliated with the laboratory of Mike Makrigiorgos at Dana Farber Cancer Institute and Harvard Medical School have demonstrated how their COLD-PCR method can be applied to epigenetics, allowing the enrichment and sequencing of rare unmethylated DNA regions in a background of highly m

SAN FRANCISCO — Scientists in the laboratory of Mike Makrigiorgos of the Dana Farber Cancer Institute and Harvard Medical School have developed a method that enriches unknown mutations of targeted DNA sequences based purely on thermal denaturation of DNA heteroduplexes without th

Transgenomic has been awarded a Phase I Small Business Technology Transfer grant from the National Institutes of Health to conduct initial studies on the feasibility of using Ice-Cold-PCR for the early detection of pancreatic cancer.

Transgenomic and the University of Texas MD Anderson Cancer Center have initiated a collaboration to evaluate Transgenomic's mutation detection technology in cancer patients, Transgenomic said this week.

This article has been updated from a version posted Nov. 7 to include information about a second distribution agreement.

COLD-PCR selectively amplifies mutant PCR "by recognizing that mutant DNA strands denature at lower temperatures in a PCR reaction than normal DNA," and Ice COLD-PCR further enhances the sensitivity of mutation detection.

Following the release of its Q4 and full-year financial results, Transgenomic updated investors on how its COLD-PCR technology may drive future revenues through diagnostic kit sales and testing services, and said that it has signed contracts with three pharma companies to explore applications for the technology.

The firm trimmed its losses and selling costs, and it expects to launch a K-Ras test shortly.

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The US Food and Drug Administration is to announce stricter standards for emergency authorizations of SARS-CoV-2 vaccines, reports the Washington Post.

The Associated Press reports Johnson & Johnson is starting a late-stage clinical trial of its candidate SARS-CoV-2 vaccine.

Bloomberg reports the budget of Operation Warp Speed is actually $18 billion, higher than the number typically cited.

In Genome Research this week: genomic analysis reveals role of super-spreaders in SARS-CoV-2, epigenetic drivers of cancer, and more.