This Week in PNAS

In PNAS this week: genetic diversity of MERS in African camels, centromere evolution in Cryptococcus, and more.

Chromatin immunoprecipitation sequencing showed divergent H4K16ac histone acetylation patterns in brain samples from young, old, and AD-affected individuals.

A genomic analysis of ependymomas from 42 patients led to nearly 1,700 suspected super enhancers, highlighting potentially targetable genes.

Researchers identified shifts in regulatory features and enhanced NOTCH signaling pathway activation in prostate tumors containing a TMPRSS2-ERG2 gene fusion.

This Week in PNAS

In PNAS this week: statistical method for gene regulation evaluation, sea urchin gene regulatory networks, and more.

Results from up to eight stages of mouse or human retina development highlight the importance of histone modifications and other epigenetic shifts during differentiation.

In Nucleic Acids Research this week: isomiR-based cancer classifier, map of VjbR binding in Brucella, and more.

New studies touched on epigenetic, regulatory, and transcriptional features for brain, kidney, and breast tumors as well as various blood cancer types. 

Members of the International Human Epigenome Consortium published several new studies describing advances in understanding immune system regulation.

Using brain samples from individuals with or without autism spectrum disorder, researchers identified H3K27ac histone acetylation marks associated with ASD.


The London School of Economics' Daniele Fanelli argues at the Proceedings of the National Academy of Sciences that the reproducibility crisis in science isn't as dire as some say.

A team of researchers in Portugal has examined the genomic basis for racing pigeons' athleticism and navigational skills, finding it's likely polygenic.

Wired reports that diagnostic firms continue to seek, post-Theranos, the ability to diagnose diseases from small amounts of blood.

In Science this week: analysis of DNA from ancient North Africans, and more.