ChIP-seq | GenomeWeb


New studies touched on epigenetic, regulatory, and transcriptional features for brain, kidney, and breast tumors as well as various blood cancer types. 

Members of the International Human Epigenome Consortium published several new studies describing advances in understanding immune system regulation.

Using brain samples from individuals with or without autism spectrum disorder, researchers identified H3K27ac histone acetylation marks associated with ASD.

In colon tissue samples from individuals with Crohn's disease, researchers discovered either colon- or ileum-like expression features.

The partners plan to improve yields from small input samples and provide better sequencing libraries.

The authors used a sequencing technique to identify secondary DNA structures, showing that they are more prevalent in cancer genes and may make good drug targets.

Tumor infiltrating cell adoptive cell therapy success in metastatic melanoma patients was associated with DNA methylation and histone acetylation changes.

This Week in Nature

In Nature this week: transcriptomic and epigenomic analysis of bat wing development, and more.

Yale researchers used a targeted ChIP-seq method on the PacBio RSII to identify a new epigenetic mark in mice stem cells that may play a role in gene silencing. 

Mayo Clinic researchers reported that the cell-specific functions of FOXA1 are influenced by genetic variations and epigenetic regulation near its binding sites.


In Science this week: genetic target for urothelial bladder cancer treatment, and more.

At the Conversation, the University of Oxford's Michael Macklay writes that learning genetic risk of disease is a personal decision.

Two dozen scientific organizations have endorsed the March for Science, according to ScienceInsider.

Researchers in Japan describe a chimpanzee with a chromosomal abnormality similar to human Down syndrome, Mashable reports.