ChIP-seq

Researchers identified shifts in regulatory features and enhanced NOTCH signaling pathway activation in prostate tumors containing a TMPRSS2-ERG2 gene fusion.

Results from up to eight stages of mouse or human retina development highlight the importance of histone modifications and other epigenetic shifts during differentiation.

New studies touched on epigenetic, regulatory, and transcriptional features for brain, kidney, and breast tumors as well as various blood cancer types. 

Members of the International Human Epigenome Consortium published several new studies describing advances in understanding immune system regulation.

Using brain samples from individuals with or without autism spectrum disorder, researchers identified H3K27ac histone acetylation marks associated with ASD.

In colon tissue samples from individuals with Crohn's disease, researchers discovered either colon- or ileum-like expression features.

The partners plan to improve yields from small input samples and provide better sequencing libraries.

The authors used a sequencing technique to identify secondary DNA structures, showing that they are more prevalent in cancer genes and may make good drug targets.