ChIP-seq

Researchers identified shifts in regulatory features and enhanced NOTCH signaling pathway activation in prostate tumors containing a TMPRSS2-ERG2 gene fusion.

This Week in PNAS

In PNAS this week: statistical method for gene regulation evaluation, sea urchin gene regulatory networks, and more.

Results from up to eight stages of mouse or human retina development highlight the importance of histone modifications and other epigenetic shifts during differentiation.

In Nucleic Acids Research this week: isomiR-based cancer classifier, map of VjbR binding in Brucella, and more.

New studies touched on epigenetic, regulatory, and transcriptional features for brain, kidney, and breast tumors as well as various blood cancer types. 

Members of the International Human Epigenome Consortium published several new studies describing advances in understanding immune system regulation.

Using brain samples from individuals with or without autism spectrum disorder, researchers identified H3K27ac histone acetylation marks associated with ASD.

In colon tissue samples from individuals with Crohn's disease, researchers discovered either colon- or ileum-like expression features.

The partners plan to improve yields from small input samples and provide better sequencing libraries.

The authors used a sequencing technique to identify secondary DNA structures, showing that they are more prevalent in cancer genes and may make good drug targets.

Pages

New Mexico is re-doing its proposed science education standards after criticism, the Associated Press reports.

Agbio executives say gene editing will speed up breeding efforts, according to the Wall Street Journal.

La Trobe University's Jenny Graves has won the $250,000 Prime Minister's Prize for Science, the Guardian reports.

In Cell this week: post-treatment changes to melanoma genome, multi-omics analysis of muscle-invasive bladder cancer, and more.