ChIP | GenomeWeb

ChIP

A team led by Buck Institute for Research on Aging scientists has reported that ApoE4 binds the promoter regions of Alzheimer's disease genes, including SirT1.

This Week in Nature

In Nature this week: mouse genome functional analysis, more sensitive chromatin immunoprecipitation, and more.

NEW YORK (GenomeWeb) — Researchers from the University of Washington have won $233,077 from the National Institute of General Medical Sciences to develop a novel chromatin immunoprecipitation platform, PIXUL-ChIP, that will integrate sample harvesting and chromatin shearing with immunoprecipitati

WaferGen Biosystems said this week that the Salk Institute for Biological Studies has established a nano-qPCR core laboratory that will feature a WaferGen SmartChip system for high-throughput, real-time PCR studies.

NEW YORK (GenomeWeb News) – A transcription factor called ELF5 may be a main determinant of breast cancer type, a team of Australian researchers reported in PLOS Biology last night.

NEW YORK (GenomeWeb News) – An international collaboration involving more than 400 researchers working to characterize gene regulatory networks in the human genome is publishing dozens of new studies this week.

By a GenomeWeb staff reporter
NEW YORK (GenomeWeb News) – Colon cancers carry a telltale set of epigenetic enhancer sites that appear to mediate gene expression shifts in the disease, according to a new online study in Science.

The method, dubbed single-tube linear DNA amplification, or LinDA, is expected to facilitate genome-wide profiling of transcription factors and chromatin analyses using DNA obtained from just a few hundred cells.

The findings represent the first demonstration that embryonic endoderm cells have distinguishing patterns of histone modification, and provide insights that could help scientists control stem cell differentiation for purposes like tissue regeneration, said one of the researchers.

Using chromatin immunoprecipitation coupled with massively parallel sequencing, researchers have shown that circadian rhythms in liver lipid metabolism are linked to oscillating interactions between the histone deacetylase 3 enzyme and genomic DNA.

Pages

In Science this week: metagenomic-based technique for determining protein structure, and more.

An academic laments the rise of narcissism in the sciences, the Guardian reports.

Outgoing FDA commissioner Robert Califf writes in an editorial that the agency can help boost innovation.

The Trump transition team has asked NIH Director Francis Collins to remain at his post, though it's unclear for how long that will be.